Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3600011..3600629 Replicon chromosome
Accession NZ_CP116181
Organism Escherichia coli strain DETEC-E480

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag PIB86_RS17755 Protein ID WP_001291435.1
Coordinates 3600411..3600629 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag PIB86_RS17750 Protein ID WP_000344800.1
Coordinates 3600011..3600385 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIB86_RS17740 (3595100) 3595100..3596293 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PIB86_RS17745 (3596316) 3596316..3599465 + 3150 WP_271287807.1 efflux RND transporter permease AcrB -
PIB86_RS17750 (3600011) 3600011..3600385 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
PIB86_RS17755 (3600411) 3600411..3600629 + 219 WP_001291435.1 HHA domain-containing protein Toxin
PIB86_RS17760 (3600803) 3600803..3601354 + 552 WP_000102539.1 maltose O-acetyltransferase -
PIB86_RS17765 (3601470) 3601470..3601940 + 471 WP_000136192.1 YlaC family protein -
PIB86_RS17770 (3602104) 3602104..3603654 + 1551 WP_001385227.1 cyclic-guanylate-specific phosphodiesterase PdeB -
PIB86_RS17775 (3603696) 3603696..3604049 - 354 WP_000878135.1 DUF1428 family protein -
PIB86_RS17785 (3604428) 3604428..3604739 + 312 WP_000409908.1 MGMT family protein -
PIB86_RS17790 (3604770) 3604770..3605342 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T268316 WP_001291435.1 NZ_CP116181:3600411-3600629 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT268316 WP_000344800.1 NZ_CP116181:3600011-3600385 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References