Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 712132..712781 Replicon chromosome
Accession NC_017522
Organism Mycobacterium tuberculosis CCDC5180

Toxin (Protein)


Gene name vapC Uniprot ID P67241
Locus tag CCDC5180_RS03265 Protein ID WP_003403236.1
Coordinates 712386..712781 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ34
Locus tag CCDC5180_RS03260 Protein ID WP_003403235.1
Coordinates 712132..712386 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCDC5180_RS20900 707257..707952 + 696 WP_003900189.1 galactose-1-phosphate uridylyltransferase -
CCDC5180_RS20905 707949..708440 + 492 WP_003905354.1 galactose-1-phosphate uridylyltransferase -
CCDC5180_RS03240 708437..709528 + 1092 WP_003900977.1 galactokinase -
CCDC5180_RS03250 709923..710987 + 1065 WP_003898532.1 hypothetical protein -
CCDC5180_RS03255 711091..712039 + 949 Protein_640 DUF732 domain-containing protein -
CCDC5180_RS03260 712132..712386 + 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 Antitoxin
CCDC5180_RS03265 712386..712781 + 396 WP_003403236.1 type II toxin-antitoxin system toxin ribonuclease C30 Toxin
CCDC5180_RS03270 712875..713615 - 741 WP_003403239.1 TVP38/TMEM64 family protein -
CCDC5180_RS03275 713747..714007 + 261 WP_003403244.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
CCDC5180_RS03280 714004..714411 + 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin -
CCDC5180_RS03285 714483..715634 - 1152 WP_003403248.1 FIST C-terminal domain-containing protein -
CCDC5180_RS03290 715729..717456 - 1728 WP_003901883.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14250.04 Da        Isoelectric Point: 4.7475

>T26831 WP_003403236.1 NC_017522:712386-712781 [Mycobacterium tuberculosis CCDC5180]
MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVIEARFGEPGGRELDLWLHRAAVDLVAVHADQADAAR
AAYRTYGKGRHRAGLNYGDCFSYGLAKISGQPLLFKGEDFQHTDIATVALP

Download         Length: 396 bp

>T26831 NC_017522:712386-712781 [Mycobacterium tuberculosis CCDC5180]
ATGGTGATCGACACGTCCGCGCTCGTTGCGATGCTCAGCGACGAGCCAGACGCAGAGCGGTTCGAGGCCGCCGTCGAAGC
CGACCACATCCGGCTGATGTCGACGGCGTCTTACCTGGAAACGGCACTCGTGATAGAAGCCCGCTTCGGTGAACCGGGCG
GACGTGAGCTGGATCTGTGGCTTCATCGCGCCGCGGTCGACCTTGTTGCCGTGCATGCCGACCAAGCGGATGCCGCGCGC
GCCGCCTACCGCACGTACGGCAAGGGAAGGCATCGTGCGGGGCTCAACTACGGCGACTGCTTCTCATACGGCCTCGCCAA
GATCAGCGGCCAGCCACTCCTGTTCAAGGGCGAAGATTTCCAACACACCGACATCGCCACGGTCGCGCTGCCCTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9139.52 Da        Isoelectric Point: 9.2702

>AT26831 WP_003403235.1 NC_017522:712132-712386 [Mycobacterium tuberculosis CCDC5180]
MALSIKHPEADRLARALAARTGETLTEAVVTALRERLARETGRARVVPLRDELAAIRHRCAALPVVDNRSAEAILGYDER
GLPA

Download         Length: 255 bp

>AT26831 NC_017522:712132-712386 [Mycobacterium tuberculosis CCDC5180]
ATGGCGCTGAGTATCAAGCACCCGGAAGCCGACCGGCTCGCGCGAGCGCTTGCGGCGCGCACCGGCGAGACGTTGACCGA
GGCAGTGGTTACCGCGTTGCGCGAGCGGCTCGCTCGTGAGACTGGGCGTGCCCGTGTTGTCCCGTTGCGCGACGAGCTTG
CCGCGATTCGGCACCGGTGCGCAGCGTTGCCGGTGGTCGACAACCGGTCCGCTGAGGCGATTCTCGGCTATGACGAGCGC
GGATTGCCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4XGR
PDB 4XGQ

Antitoxin

Source ID Structure
PDB 4XGR
PDB 4XGQ
AlphaFold DB A0A7U4BSC2

References