Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 4399194..4399825 Replicon chromosome
Accession NZ_CP116176
Organism Escherichia coli strain DETEC-E601

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag PIC02_RS21400 Protein ID WP_001259385.1
Coordinates 4399550..4399825 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag PIC02_RS21395 Protein ID WP_000593555.1
Coordinates 4399194..4399553 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC02_RS21370 (4395326) 4395326..4396270 + 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -
PIC02_RS21375 (4396267) 4396267..4397100 + 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
PIC02_RS21380 (4397100) 4397100..4397864 + 765 WP_001136235.1 nickel import ATP-binding protein NikD -
PIC02_RS21385 (4397861) 4397861..4398667 + 807 WP_000173666.1 nickel import ATP-binding protein NikE -
PIC02_RS21390 (4398673) 4398673..4399074 + 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
PIC02_RS21395 (4399194) 4399194..4399553 - 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PIC02_RS21400 (4399550) 4399550..4399825 - 276 WP_001259385.1 type II toxin-antitoxin system HicA family toxin Toxin
PIC02_RS21405 (4399898) 4399898..4401022 - 1125 WP_001314210.1 ABC transporter permease -
PIC02_RS21410 (4401022) 4401022..4403757 - 2736 WP_000149132.1 ribosome-associated ATPase/putative transporter RbbA -
PIC02_RS21415 (4403754) 4403754..4404821 - 1068 WP_000361485.1 HlyD family secretion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T268298 WP_001259385.1 NZ_CP116176:c4399825-4399550 [Escherichia coli]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT268298 WP_000593555.1 NZ_CP116176:c4399553-4399194 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TTW8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References