Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3800974..3801628 Replicon chromosome
Accession NZ_CP116176
Organism Escherichia coli strain DETEC-E601

Toxin (Protein)


Gene name cptA Uniprot ID F4NJ21
Locus tag PIC02_RS18360 Protein ID WP_000244772.1
Coordinates 3800974..3801381 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag PIC02_RS18365 Protein ID WP_000354046.1
Coordinates 3801362..3801628 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC02_RS18340 (3796931) 3796931..3798664 - 1734 WP_000813211.1 single-stranded-DNA-specific exonuclease RecJ -
PIC02_RS18345 (3798670) 3798670..3799380 - 711 WP_000715212.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PIC02_RS18350 (3799405) 3799405..3800301 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
PIC02_RS18355 (3800413) 3800413..3800934 + 522 WP_001055874.1 flavodoxin FldB -
PIC02_RS18360 (3800974) 3800974..3801381 - 408 WP_000244772.1 protein YgfX Toxin
PIC02_RS18365 (3801362) 3801362..3801628 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
PIC02_RS18370 (3801871) 3801871..3802851 + 981 WP_000886064.1 tRNA-modifying protein YgfZ -
PIC02_RS18375 (3802928) 3802928..3803587 - 660 WP_000250274.1 hemolysin III family protein -
PIC02_RS18380 (3803751) 3803751..3804062 - 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
PIC02_RS18385 (3804107) 3804107..3805540 + 1434 WP_001344773.1 6-phospho-beta-glucosidase BglA -
PIC02_RS18390 (3805597) 3805597..3806340 - 744 WP_000951964.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16048.02 Da        Isoelectric Point: 11.2511

>T268296 WP_000244772.1 NZ_CP116176:c3801381-3800974 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT268296 WP_000354046.1 NZ_CP116176:c3801628-3801362 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XYB4

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References