Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3357603..3358228 Replicon chromosome
Accession NZ_CP116176
Organism Escherichia coli strain DETEC-E601

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag PIC02_RS16230 Protein ID WP_000911329.1
Coordinates 3357603..3358001 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag PIC02_RS16235 Protein ID WP_000450524.1
Coordinates 3358001..3358228 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC02_RS16210 (3353510) 3353510..3353710 + 201 WP_000383836.1 YpfN family protein -
PIC02_RS16215 (3353791) 3353791..3354489 - 699 WP_000679812.1 esterase -
PIC02_RS16220 (3354563) 3354563..3356578 - 2016 WP_236930000.1 tRNA cytosine(34) acetyltransferase TmcA -
PIC02_RS16225 (3356593) 3356593..3357456 - 864 WP_001267495.1 neutral zinc metallopeptidase -
PIC02_RS16230 (3357603) 3357603..3358001 - 399 WP_000911329.1 type II toxin-antitoxin system VapC family toxin Toxin
PIC02_RS16235 (3358001) 3358001..3358228 - 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
PIC02_RS16240 (3358383) 3358383..3359096 - 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
PIC02_RS16245 (3359309) 3359309..3360343 - 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
PIC02_RS16250 (3360360) 3360360..3361238 - 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
PIC02_RS16255 (3361384) 3361384..3361956 + 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
PIC02_RS16260 (3361956) 3361956..3362426 + 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T268294 WP_000911329.1 NZ_CP116176:c3358001-3357603 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT268294 WP_000450524.1 NZ_CP116176:c3358228-3358001 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References