Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 698965..699608 Replicon chromosome
Accession NC_017522
Organism Mycobacterium tuberculosis CCDC5180

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag CCDC5180_RS03175 Protein ID WP_003403187.1
Coordinates 699207..699608 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag CCDC5180_RS03170 Protein ID WP_003403184.1
Coordinates 698965..699210 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCDC5180_RS03135 694244..694774 - 531 WP_003917320.1 two component system sensor kinase HK2 -
CCDC5180_RS03140 694758..695453 - 696 WP_003918099.1 two-component system response regulator TcrA -
CCDC5180_RS03145 695679..695888 + 210 WP_138021278.1 PepSY domain-containing protein -
CCDC5180_RS03150 695960..696910 + 951 WP_003900184.1 DUF1259 domain-containing protein -
CCDC5180_RS03155 697151..697735 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
CCDC5180_RS03160 697737..698450 + 714 Protein_622 IS607 family element transposase accessory protein TnpB -
CCDC5180_RS03165 698450..698920 + 471 WP_003898523.1 hypothetical protein -
CCDC5180_RS03170 698965..699210 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
CCDC5180_RS03175 699207..699608 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
CCDC5180_RS22220 699996..700163 - 168 WP_077385191.1 DUF3800 domain-containing protein -
CCDC5180_RS22225 700196..700393 - 198 WP_003403191.1 hypothetical protein -
CCDC5180_RS03190 700473..701630 - 1158 WP_003898524.1 hypothetical protein -
CCDC5180_RS03195 701682..701903 - 222 WP_003898525.1 DUF4926 domain-containing protein -
CCDC5180_RS03200 702045..702650 + 606 WP_003898526.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T26829 WP_003403187.1 NC_017522:699207-699608 [Mycobacterium tuberculosis CCDC5180]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

>T26829 NC_017522:699207-699608 [Mycobacterium tuberculosis CCDC5180]
GTGATCGTCGACACGTCGGCGATCATCGCGATTCTGCGCGACGAGGACGACGCCGCGGCCTACGCCGACGCGCTCGCCAA
CGCCGATGTCCGCAGACTGTCTGCGGCCAGCTACCTGGAATGCGGGATAGTCCTTGACTCCCAGCGTGATCCGGTCATCA
GCAGAGCACTGGATGAACTTATCGAAGAAGCCGAGTTCGTCGTCGAGCCGGTAACCGAGCGCCAGGCCCGCCTGGCCCGA
GCGGCCTACGCGGATTTCGGCAGAGGCAGCGGCCACCCCGCGGGCTTGAATTTCGGCGACTGCCTGTCCTATGCACTGGC
GATCGATCGACGTGAGCCGCTGCTGTGGAAGGGCAACGACTTTGGGCACACCGGCGTCCAAAGGGCACTGGATCGGCGGT
GA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT26829 WP_003403184.1 NC_017522:698965-699210 [Mycobacterium tuberculosis CCDC5180]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp

>AT26829 NC_017522:698965-699210 [Mycobacterium tuberculosis CCDC5180]
ATGGCGTTGAACATCAAAGATCCGTCGGTTCACCAGGCGGTCAAGCAGATCGCGAAAATCACCGGCGAATCTCAGGCTCG
GGCGGTGGCGACCGCGGTGAACGAGCGTCTGGCCAGACTGCGCAGCGACGATCTCGCCGCCCGGCTCTTGGCTATCGGCC
ACAAGACCGCGAGCAGGATGAGCCCGGAAGCAAAGCGCCTCGACCACGATGCTCTGCTGTATGACGAGCGAGGGCTGCCG
GCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References