Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1181311..1181929 Replicon chromosome
Accession NZ_CP116176
Organism Escherichia coli strain DETEC-E601

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag PIC02_RS05605 Protein ID WP_001291435.1
Coordinates 1181311..1181529 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag PIC02_RS05610 Protein ID WP_000344800.1
Coordinates 1181555..1181929 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC02_RS05570 (1176601) 1176601..1177173 + 573 WP_000779826.1 YbaY family lipoprotein -
PIC02_RS05575 (1177204) 1177204..1177515 - 312 WP_000409911.1 MGMT family protein -
PIC02_RS05585 (1177894) 1177894..1178247 + 354 WP_000878141.1 DUF1428 family protein -
PIC02_RS05590 (1178289) 1178289..1179839 - 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
PIC02_RS05595 (1180003) 1180003..1180473 - 471 WP_000136192.1 YlaC family protein -
PIC02_RS05600 (1180589) 1180589..1181140 - 552 WP_000102564.1 maltose O-acetyltransferase -
PIC02_RS05605 (1181311) 1181311..1181529 - 219 WP_001291435.1 HHA domain-containing protein Toxin
PIC02_RS05610 (1181555) 1181555..1181929 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
PIC02_RS05615 (1182475) 1182475..1185624 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
PIC02_RS05620 (1185647) 1185647..1186840 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T268287 WP_001291435.1 NZ_CP116176:c1181529-1181311 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT268287 WP_000344800.1 NZ_CP116176:c1181929-1181555 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References