Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 2275..2822 Replicon plasmid pDETEC82
Accession NZ_CP116171
Organism Escherichia coli strain DETEC-P1056

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag PIC86_RS23705 Protein ID WP_013009346.1
Coordinates 2544..2822 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E0WH52
Locus tag PIC86_RS23700 Protein ID WP_000079932.1
Coordinates 2275..2544 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC86_RS23690 (PIC86_23685) 495..1367 + 873 WP_000729438.1 incFII family plasmid replication initiator RepA -
PIC86_RS23695 (PIC86_23690) 2062..2220 + 159 WP_000829588.1 hypothetical protein -
PIC86_RS23700 (PIC86_23695) 2275..2544 + 270 WP_000079932.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
PIC86_RS23705 (PIC86_23700) 2544..2822 + 279 WP_013009346.1 type II toxin-antitoxin system toxin YacB Toxin
PIC86_RS23710 (PIC86_23705) 3018..3314 - 297 WP_001419651.1 hypothetical protein -
PIC86_RS23715 (PIC86_23710) 3659..4246 + 588 WP_001418189.1 serine acetyltransferase -
PIC86_RS23720 (PIC86_23715) 4528..5121 - 594 WP_001401779.1 ProQ/FINO family protein -
PIC86_RS23725 (PIC86_23720) 5475..6821 + 1347 WP_001132021.1 protein YagA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaCTX-M-14 - 1..88352 88352
- flank IS/Tn - - 7153..7857 704


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10748.35 Da        Isoelectric Point: 8.4615

>T268283 WP_013009346.1 NZ_CP116171:2544-2822 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
VLRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10268.58 Da        Isoelectric Point: 7.2055

>AT268283 WP_000079932.1 NZ_CP116171:2275-2544 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVSDK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5U8RN22

References