Detailed information of TA system TA026828

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/AbrB(antitoxin)
• Location: 692874..693520
• Replicon: chromosome
• Accession: NC_017522
• Organism: Mycobacterium tuberculosis CCDC5180

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TQ88
• Locus tag: CCDC5180_RS03120
• Protein ID: WP_003403137.1
• Coordinates: 692874..693287 (-)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TQ89
• Locus tag: CCDC5180_RS03125
• Protein ID: WP_003403139.1
• Coordinates: 693284..693520 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CCDC5180_RS03100	688957..690507	+	1551	WP_003905349.1	MCE family protein	-
CCDC5180_RS03105	690559..690951	-	393	WP_003403122.1	type II toxin-antitoxin system toxin ribonuclease C4	-
CCDC5180_RS03110	690948..691205	-	258	WP_003403125.1	type II toxin-antitoxin system antitoxin VapB4	-
CCDC5180_RS03115	691388..692623	-	1236	WP_003403128.1	ATP-binding protein	-
CCDC5180_RS03120	692874..693287	-	414	WP_003403137.1	type II toxin-antitoxin system VapC family toxin	Toxin
CCDC5180_RS03125	693284..693520	-	237	WP_003403139.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
CCDC5180_RS03130	693624..694130	-	507	WP_003900973.1	two component system sensor kinase HK1	-
CCDC5180_RS03135	694244..694774	-	531	WP_003917320.1	two component system sensor kinase HK2	-
CCDC5180_RS03140	694758..695453	-	696	WP_003918099.1	two-component system response regulator TcrA	-
CCDC5180_RS03145	695679..695888	+	210	WP_138021278.1	PepSY domain-containing protein	-
CCDC5180_RS03150	695960..696910	+	951	WP_003900184.1	DUF1259 domain-containing protein	-
CCDC5180_RS03155	697151..697735	+	585	WP_003403171.1	IS607-like element IS1536 family transposase	-
CCDC5180_RS03160	697737..698450	+	714	Protein_622	IS607 family element transposase accessory protein TnpB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (7-126)

Antitoxin

• SpoVT-AbrB domain (3-43)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 14786.14 Da
• Isoelectric Point: 8.1405

>T26828 WP_003403137.1 NC_017522:c693287-692874 [Mycobacterium tuberculosis CCDC5180]
VKPPLAVDTSVAIPLLVRTHTAHAAVVAWWAHREAALCGHALAETYSVLTRLPRDLRLAPMDAARLLTERFAAPLLLSSR
TTEHLPRVLAQFEITGGAVYDALVALAAAEHRAELATRDARAKDTYEKIGVHVVVAA

Nucleotide

• Length: 414 bp

>T26828 NC_017522:c693287-692874 [Mycobacterium tuberculosis CCDC5180]
GTGAAACCGCCGCTGGCAGTGGACACCAGCGTCGCGATTCCGTTGCTGGTACGGACCCATACCGCGCATGCGGCGGTTGT
CGCCTGGTGGGCACATCGGGAGGCCGCGCTGTGCGGGCACGCCCTGGCCGAAACCTACTCCGTGCTGACCCGCCTGCCGC
GTGACCTACGACTGGCACCGATGGACGCCGCGCGGCTTCTTACCGAACGCTTTGCGGCACCGCTGTTGTTGAGTTCCCGC
ACCACTGAACATCTCCCACGCGTGCTGGCCCAATTCGAGATCACTGGTGGCGCGGTCTATGACGCTCTCGTGGCCCTTGC
CGCCGCCGAGCACCGGGCTGAACTCGCCACACGCGATGCTCGAGCCAAGGACACTTACGAAAAGATCGGCGTCCACGTCG
TTGTCGCCGCGTGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8212.41 Da
• Isoelectric Point: 5.0351

>AT26828 WP_003403139.1 NC_017522:c693520-693284 [Mycobacterium tuberculosis CCDC5180]
MKAVVDAAGRIVVPKPLREALGLQPGSTVEISRYGAGLHLIPTGRTARLEEENGVLVATGETTIDDEVVFGLIDSGRK

Nucleotide

• Length: 237 bp

>AT26828 NC_017522:c693520-693284 [Mycobacterium tuberculosis CCDC5180]
ATGAAGGCTGTTGTGGATGCGGCTGGCCGCATCGTCGTACCCAAACCGCTGCGCGAAGCCTTGGGGCTGCAACCGGGGTC
CACCGTGGAAATATCCCGCTATGGCGCTGGTCTCCACCTGATTCCCACCGGACGAACAGCGCGTCTCGAAGAGGAGAATG
GCGTACTGGTGGCCACCGGTGAGACCACGATCGACGATGAGGTCGTGTTCGGCCTTATCGATAGCGGCCGGAAGTGA

Structures

Toxin

• AlphaFold DB: G0TQ88

Antitoxin

• AlphaFold DB: G0TQ89