Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3460476..3461094 Replicon chromosome
Accession NZ_CP116169
Organism Escherichia coli strain DETEC-P1056

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag PIC86_RS16865 Protein ID WP_001291435.1
Coordinates 3460876..3461094 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag PIC86_RS16860 Protein ID WP_000344800.1
Coordinates 3460476..3460850 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC86_RS16850 (3455565) 3455565..3456758 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PIC86_RS16855 (3456781) 3456781..3459930 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
PIC86_RS16860 (3460476) 3460476..3460850 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
PIC86_RS16865 (3460876) 3460876..3461094 + 219 WP_001291435.1 HHA domain-containing protein Toxin
PIC86_RS16870 (3461266) 3461266..3461817 + 552 WP_000102568.1 maltose O-acetyltransferase -
PIC86_RS16875 (3461933) 3461933..3462403 + 471 WP_000136192.1 YlaC family protein -
PIC86_RS16880 (3462567) 3462567..3464117 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
PIC86_RS16885 (3464159) 3464159..3464512 - 354 WP_000878140.1 DUF1428 domain-containing protein -
PIC86_RS16895 (3464891) 3464891..3465202 + 312 WP_000409911.1 MGMT family protein -
PIC86_RS16900 (3465233) 3465233..3465805 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T268272 WP_001291435.1 NZ_CP116169:3460876-3461094 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT268272 WP_000344800.1 NZ_CP116169:3460476-3460850 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References