Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 690559..691205 Replicon chromosome
Accession NC_017522
Organism Mycobacterium tuberculosis CCDC5180

Toxin (Protein)


Gene name vapC Uniprot ID O07783
Locus tag CCDC5180_RS03105 Protein ID WP_003403122.1
Coordinates 690559..690951 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ86
Locus tag CCDC5180_RS03110 Protein ID WP_003403125.1
Coordinates 690948..691205 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCDC5180_RS03090 686220..687747 + 1528 Protein_608 virulence factor Mce family protein -
CCDC5180_RS03095 687810..688952 + 1143 WP_003911253.1 virulence factor Mce family protein -
CCDC5180_RS03100 688957..690507 + 1551 WP_003905349.1 MCE family protein -
CCDC5180_RS03105 690559..690951 - 393 WP_003403122.1 type II toxin-antitoxin system toxin ribonuclease C4 Toxin
CCDC5180_RS03110 690948..691205 - 258 WP_003403125.1 type II toxin-antitoxin system antitoxin VapB4 Antitoxin
CCDC5180_RS03115 691388..692623 - 1236 WP_003403128.1 ATP-binding protein -
CCDC5180_RS03120 692874..693287 - 414 WP_003403137.1 type II toxin-antitoxin system VapC family toxin -
CCDC5180_RS03125 693284..693520 - 237 WP_003403139.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
CCDC5180_RS03130 693624..694130 - 507 WP_003900973.1 two component system sensor kinase HK1 -
CCDC5180_RS03135 694244..694774 - 531 WP_003917320.1 two component system sensor kinase HK2 -
CCDC5180_RS03140 694758..695453 - 696 WP_003918099.1 two-component system response regulator TcrA -
CCDC5180_RS03145 695679..695888 + 210 WP_138021278.1 PepSY domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-53)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14080.08 Da        Isoelectric Point: 4.6558

>T26827 WP_003403122.1 NC_017522:c690951-690559 [Mycobacterium tuberculosis CCDC5180]
VNVRRALADTSVFIGIEATRFDPDRFAGYEWGVSVVTLGELRLGVLQASGPEAAARRLSTYQLAQRFEPLGIDEAVSEAW
ALLVSKLRAAKLRVPINDSWIAATAVAHGIAILTQDNDYAAMPDVEVITI

Download         Length: 393 bp

>T26827 NC_017522:c690951-690559 [Mycobacterium tuberculosis CCDC5180]
GTGAACGTACGGCGCGCCCTCGCCGACACATCCGTTTTCATTGGCATCGAGGCGACACGATTCGACCCGGACCGGTTTGC
GGGATACGAATGGGGCGTCTCGGTAGTCACACTCGGCGAGCTGCGGCTCGGGGTGTTGCAAGCCTCCGGCCCCGAGGCCG
CCGCACGTCGGCTCTCCACCTACCAGCTTGCGCAACGGTTCGAACCACTAGGCATCGACGAGGCGGTCTCCGAAGCATGG
GCATTACTGGTGTCCAAGCTGCGCGCCGCCAAACTGCGCGTGCCGATCAACGACAGCTGGATTGCGGCCACAGCCGTGGC
GCACGGCATTGCGATCCTGACCCAAGACAACGACTACGCCGCCATGCCCGACGTCGAGGTCATAACGATCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9681.06 Da        Isoelectric Point: 7.0175

>AT26827 WP_003403125.1 NC_017522:c691205-690948 [Mycobacterium tuberculosis CCDC5180]
MSATIPARDLRNHTAEVLRRVAAGEEIEVLKDNRPVARIVPLKRRRQWLPAAEVIGELVRLGPDTTNLGEELRETLTQTT
DDVRW

Download         Length: 258 bp

>AT26827 NC_017522:c691205-690948 [Mycobacterium tuberculosis CCDC5180]
ATGTCTGCTACGATACCCGCTCGCGATCTTCGCAACCACACCGCCGAGGTACTGCGGCGAGTTGCCGCCGGCGAGGAAAT
CGAGGTGCTCAAGGACAATCGCCCCGTAGCGCGCATCGTTCCGCTCAAGCGGCGCCGCCAATGGTTGCCAGCTGCCGAGG
TGATCGGCGAACTGGTGCGCTTGGGCCCCGATACCACCAATCTGGGCGAGGAGCTGCGAGAGACGCTGACGCAAACCACG
GACGATGTGCGGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F8V4

Antitoxin

Source ID Structure
AlphaFold DB G0TQ86

References