Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1341047..1341672 Replicon chromosome
Accession NZ_CP116169
Organism Escherichia coli strain DETEC-P1056

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PIC86_RS06565 Protein ID WP_000911330.1
Coordinates 1341274..1341672 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag PIC86_RS06560 Protein ID WP_000450524.1
Coordinates 1341047..1341274 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC86_RS06535 (1336850) 1336850..1337320 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
PIC86_RS06540 (1337320) 1337320..1337892 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
PIC86_RS06545 (1338038) 1338038..1338916 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
PIC86_RS06550 (1338933) 1338933..1339967 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
PIC86_RS06555 (1340180) 1340180..1340893 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
PIC86_RS06560 (1341047) 1341047..1341274 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
PIC86_RS06565 (1341274) 1341274..1341672 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
PIC86_RS06570 (1341819) 1341819..1342682 + 864 WP_001267508.1 neutral zinc metallopeptidase -
PIC86_RS06575 (1342697) 1342697..1344712 + 2016 WP_000829329.1 tRNA cytosine(34) acetyltransferase TmcA -
PIC86_RS06580 (1344786) 1344786..1345484 + 699 WP_000679823.1 esterase -
PIC86_RS06585 (1345594) 1345594..1345794 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T268263 WP_000911330.1 NZ_CP116169:1341274-1341672 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT268263 WP_000450524.1 NZ_CP116169:1341047-1341274 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References