Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 880269..880923 Replicon chromosome
Accession NZ_CP116169
Organism Escherichia coli strain DETEC-P1056

Toxin (Protein)


Gene name cptA Uniprot ID F4NJ21
Locus tag PIC86_RS04300 Protein ID WP_000244772.1
Coordinates 880516..880923 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag PIC86_RS04295 Protein ID WP_000354046.1
Coordinates 880269..880535 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC86_RS04270 (875557) 875557..876300 + 744 WP_000951964.1 SDR family oxidoreductase -
PIC86_RS04275 (876357) 876357..877790 - 1434 WP_001363803.1 6-phospho-beta-glucosidase BglA -
PIC86_RS04280 (877835) 877835..878146 + 312 WP_001182944.1 N(4)-acetylcytidine aminohydrolase -
PIC86_RS04285 (878310) 878310..878969 + 660 WP_000250274.1 hemolysin III family protein -
PIC86_RS04290 (879046) 879046..880026 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
PIC86_RS04295 (880269) 880269..880535 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
PIC86_RS04300 (880516) 880516..880923 + 408 WP_000244772.1 protein YgfX Toxin
PIC86_RS04305 (880963) 880963..881484 - 522 WP_001055874.1 flavodoxin FldB -
PIC86_RS04310 (881596) 881596..882492 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
PIC86_RS04315 (882517) 882517..883227 + 711 WP_109556823.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PIC86_RS04320 (883233) 883233..884966 + 1734 WP_000813215.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16048.02 Da        Isoelectric Point: 11.2511

>T268261 WP_000244772.1 NZ_CP116169:880516-880923 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT268261 WP_000354046.1 NZ_CP116169:880269-880535 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XYB4

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References