Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1335963..1336588 Replicon chromosome
Accession NZ_CP116166
Organism Escherichia coli strain DETEC-P169

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PID12_RS06515 Protein ID WP_000911330.1
Coordinates 1336190..1336588 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag PID12_RS06510 Protein ID WP_000450524.1
Coordinates 1335963..1336190 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PID12_RS06485 (1331766) 1331766..1332236 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
PID12_RS06490 (1332236) 1332236..1332808 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
PID12_RS06495 (1332954) 1332954..1333832 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
PID12_RS06500 (1333849) 1333849..1334883 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
PID12_RS06505 (1335096) 1335096..1335809 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
PID12_RS06510 (1335963) 1335963..1336190 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
PID12_RS06515 (1336190) 1336190..1336588 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
PID12_RS06520 (1336735) 1336735..1337598 + 864 WP_001267507.1 neutral zinc metallopeptidase -
PID12_RS06525 (1337613) 1337613..1339628 + 2016 WP_000829323.1 tRNA cytosine(34) acetyltransferase TmcA -
PID12_RS06530 (1339702) 1339702..1340400 + 699 WP_000679823.1 esterase -
PID12_RS06535 (1340510) 1340510..1340710 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T268239 WP_000911330.1 NZ_CP116166:1336190-1336588 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT268239 WP_000450524.1 NZ_CP116166:1335963-1336190 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References