Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 297116..297702 Replicon chromosome
Accession NZ_CP116166
Organism Escherichia coli strain DETEC-P169

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag PID12_RS01345 Protein ID WP_042014162.1
Coordinates 297116..297346 (+) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag PID12_RS01350 Protein ID WP_000593555.1
Coordinates 297343..297702 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PID12_RS01335 (293153) 293153..295888 + 2736 WP_000149132.1 ribosome-associated ATPase/putative transporter RbbA -
PID12_RS01340 (295888) 295888..297012 + 1125 WP_001314210.1 ABC transporter permease -
PID12_RS01345 (297116) 297116..297346 + 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
PID12_RS01350 (297343) 297343..297702 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PID12_RS01355 (297822) 297822..298223 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
PID12_RS01360 (298229) 298229..299035 - 807 WP_000173666.1 nickel import ATP-binding protein NikE -
PID12_RS01365 (299032) 299032..299796 - 765 WP_001136236.1 nickel import ATP-binding protein NikD -
PID12_RS01370 (299796) 299796..300629 - 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
PID12_RS01375 (300626) 300626..301570 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T268232 WP_042014162.1 NZ_CP116166:297116-297346 [Escherichia coli]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT268232 WP_000593555.1 NZ_CP116166:297343-297702 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References