Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 102581..103206 Replicon plasmid pDETEC5
Accession NZ_CP116160
Organism Escherichia coli strain DETEC-P351

Toxin (Protein)


Gene name vapC Uniprot ID A0A1D7QA53
Locus tag PIC26_RS23790 Protein ID WP_039023147.1
Coordinates 102581..102979 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1D7QA08
Locus tag PIC26_RS23795 Protein ID WP_039023146.1
Coordinates 102979..103206 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC26_RS23775 (98834) 98834..99331 + 498 WP_000605862.1 entry exclusion protein -
PIC26_RS23780 (99363) 99363..100094 + 732 WP_000850422.1 conjugal transfer complement resistance protein TraT -
PIC26_RS23785 (100347) 100347..102572 + 2226 WP_106493937.1 type IV conjugative transfer system coupling protein TraD -
PIC26_RS23790 (102581) 102581..102979 - 399 WP_039023147.1 type II toxin-antitoxin system VapC family toxin Toxin
PIC26_RS23795 (102979) 102979..103206 - 228 WP_039023146.1 toxin-antitoxin system antitoxin VapB Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid tet(A) / dfrA17 / aadA5 / qacE / sul1 / mph(A) - 1..116501 116501


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-43)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14885.26 Da        Isoelectric Point: 8.2824

>T268227 WP_039023147.1 NZ_CP116160:c102979-102581 [Escherichia coli]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAAIHT
GQIRAELARQGRPVGPFDQMIAGHARCRGLIIVTNNTREFERVGGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8549.62 Da        Isoelectric Point: 4.7513

>AT268227 WP_039023146.1 NZ_CP116160:c103206-102979 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPENVKRVEVIAIGRTRLITPAGETWDEWFDGHSVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7QA53

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7QA08

References