Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3496692..3497310 Replicon chromosome
Accession NZ_CP116159
Organism Escherichia coli strain DETEC-P351

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag PIC26_RS16915 Protein ID WP_001291435.1
Coordinates 3497092..3497310 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag PIC26_RS16910 Protein ID WP_271286571.1
Coordinates 3496692..3497066 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC26_RS16900 (3491781) 3491781..3492974 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PIC26_RS16905 (3492997) 3492997..3496146 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
PIC26_RS16910 (3496692) 3496692..3497066 + 375 WP_271286571.1 Hha toxicity modulator TomB Antitoxin
PIC26_RS16915 (3497092) 3497092..3497310 + 219 WP_001291435.1 HHA domain-containing protein Toxin
PIC26_RS16920 (3497482) 3497482..3498033 + 552 WP_000102564.1 maltose O-acetyltransferase -
PIC26_RS16925 (3498149) 3498149..3498619 + 471 WP_000136192.1 YlaC family protein -
PIC26_RS16930 (3498783) 3498783..3500333 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
PIC26_RS16935 (3500375) 3500375..3500728 - 354 WP_000878140.1 DUF1428 domain-containing protein -
PIC26_RS16945 (3501107) 3501107..3501418 + 312 WP_000409911.1 MGMT family protein -
PIC26_RS16950 (3501449) 3501449..3502021 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T268216 WP_001291435.1 NZ_CP116159:3497092-3497310 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14543.36 Da        Isoelectric Point: 4.7395

>AT268216 WP_271286571.1 NZ_CP116159:3496692-3497066 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSGINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure

References