Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 108025..108668 Replicon plasmid pDETEC38
Accession NZ_CP116154
Organism Escherichia coli strain DETEC-P61

Toxin (Protein)


Gene name vagD Uniprot ID V0UN72
Locus tag PIC71_RS24215 Protein ID WP_001034044.1
Coordinates 108252..108668 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B1P7N7
Locus tag PIC71_RS24210 Protein ID WP_001261286.1
Coordinates 108025..108255 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC71_RS24195 (103162) 103162..103392 + 231 WP_001261278.1 type II toxin-antitoxin system VapB family antitoxin -
PIC71_RS24200 (103389) 103389..103805 + 417 WP_001034046.1 type II toxin-antitoxin system VapC family toxin -
PIC71_RS24205 (103850) 103850..107644 - 3795 WP_001144732.1 hypothetical protein -
PIC71_RS24210 (108025) 108025..108255 + 231 WP_001261286.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
PIC71_RS24215 (108252) 108252..108668 + 417 WP_001034044.1 type II toxin-antitoxin system VapC family toxin Toxin
PIC71_RS24220 (108743) 108743..110308 + 1566 WP_001128474.1 AAA family ATPase -
PIC71_RS24225 (110293) 110293..111315 + 1023 WP_000361402.1 helicase UvrD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid ant(3'')-Ia / mph(A) / blaNDM-5 / sitABCD iutA / iucD / iucC / iucB / iucA 1..128466 128466
- flank IS/Tn - - 111569..111946 377


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15232.66 Da        Isoelectric Point: 6.8536

>T268201 WP_001034044.1 NZ_CP116154:108252-108668 [Escherichia coli]
VNKIYMLDTNICSFIMREQPEALLKHLEQSVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCERLDAVLPWDRA
AVDATTEIKVALRLAGTPIGPNDTAIAGHAIAACAILVTNNVREFERVPGLVLEDWVR

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8747.86 Da        Isoelectric Point: 4.3775

>AT268201 WP_001261286.1 NZ_CP116154:108025-108255 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLELEKADPDFMTEREDVVSDEGRVNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CHW1

Antitoxin

Source ID Structure
AlphaFold DB A0A829CKZ6

References