Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 77361..77896 Replicon plasmid pDETEC37
Accession NZ_CP116153
Organism Escherichia coli strain DETEC-P61

Toxin (Protein)


Gene name relE Uniprot ID A0A0K4CX11
Locus tag PIC71_RS23255 Protein ID WP_000222771.1
Coordinates 77609..77896 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID T1PXV2
Locus tag PIC71_RS23250 Protein ID WP_001139206.1
Coordinates 77361..77612 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC71_RS23245 (PIC71_23245) 72811..76701 - 3891 WP_250694170.1 helicase-related protein -
PIC71_RS23250 (PIC71_23250) 77361..77612 + 252 WP_001139206.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PIC71_RS23255 (PIC71_23255) 77609..77896 + 288 WP_000222771.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PIC71_RS23260 (PIC71_23260) 78264..78377 - 114 Protein_84 alkaline phosphatase -
PIC71_RS23265 (PIC71_23265) 78376..78581 + 206 Protein_85 hypothetical protein -
PIC71_RS23270 (PIC71_23270) 78756..82271 - 3516 WP_072664206.1 autotransporter outer membrane beta-barrel domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid mph(A) / sul1 / qacE / qnrB6 / aadA16 / dfrA27 / ARR-3 / aac(6')-Ib-cr / oqxB / oqxA / aph(3'')-Ib / aph(6)-Id - 1..142064 142064


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11116.17 Da        Isoelectric Point: 10.5833

>T268194 WP_000222771.1 NZ_CP116153:77609-77896 [Escherichia coli]
MTYTVKFRDDALKEWLRLDKTIQQQFAKKLKKCSENPHIASAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSNVYHLASERMK

Download         Length: 288 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9171.39 Da        Isoelectric Point: 4.0927

>AT268194 WP_001139206.1 NZ_CP116153:77361-77612 [Escherichia coli]
MPSIILSDTSASVSELKKNPMATVSAGEGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSSQPLHDVDLD
SYL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K4CX11

Antitoxin

Source ID Structure
AlphaFold DB T1PXV2

References