Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4161741..4162238 Replicon chromosome
Accession NZ_CP116152
Organism Escherichia coli strain DETEC-P61

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag PIC71_RS20655 Protein ID WP_001173343.1
Coordinates 4161741..4161914 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID J7RC38
Locus tag PIC71_RS20660 Protein ID WP_001425728.1
Coordinates 4161942..4162238 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC71_RS20645 (4158411) 4158411..4159868 + 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -
PIC71_RS20650 (4160105) 4160105..4161622 + 1518 WP_001295074.1 lysine--tRNA ligase -
PIC71_RS20655 (4161741) 4161741..4161914 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
PIC71_RS20660 (4161942) 4161942..4162238 - 297 WP_001425728.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
PIC71_RS20665 (4162465) 4162465..4162737 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
PIC71_RS20670 (4162749) 4162749..4162979 - 231 WP_000371700.1 4Fe-4S mono-cluster protein YjdI -
PIC71_RS20675 (4163160) 4163160..4164791 + 1632 WP_001216486.1 sensor histidine kinase -
PIC71_RS20680 (4164788) 4164788..4165507 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T268192 WP_001173343.1 NZ_CP116152:c4161914-4161741 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11466.99 Da        Isoelectric Point: 4.2544

>AT268192 WP_001425728.1 NZ_CP116152:c4162238-4161942 [Escherichia coli]
MEGKNKFNTYVVSFNYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB J7RC38

References