Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3380702..3381320 Replicon chromosome
Accession NZ_CP116152
Organism Escherichia coli strain DETEC-P61

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag PIC71_RS16735 Protein ID WP_001291435.1
Coordinates 3381102..3381320 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag PIC71_RS16730 Protein ID WP_000344800.1
Coordinates 3380702..3381076 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC71_RS16720 (3375791) 3375791..3376984 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PIC71_RS16725 (3377007) 3377007..3380156 + 3150 WP_096257319.1 efflux RND transporter permease AcrB -
PIC71_RS16730 (3380702) 3380702..3381076 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
PIC71_RS16735 (3381102) 3381102..3381320 + 219 WP_001291435.1 HHA domain-containing protein Toxin
PIC71_RS16740 (3381492) 3381492..3382043 + 552 WP_000102564.1 maltose O-acetyltransferase -
PIC71_RS16745 (3382159) 3382159..3382629 + 471 WP_000136192.1 YlaC family protein -
PIC71_RS16750 (3382793) 3382793..3384343 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
PIC71_RS16755 (3384385) 3384385..3384738 - 354 WP_000878140.1 DUF1428 domain-containing protein -
PIC71_RS16765 (3385117) 3385117..3385428 + 312 WP_000409911.1 MGMT family protein -
PIC71_RS16770 (3385459) 3385459..3386031 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T268189 WP_001291435.1 NZ_CP116152:3381102-3381320 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT268189 WP_000344800.1 NZ_CP116152:3380702-3381076 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References