Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2396649..2397287 Replicon chromosome
Accession NZ_CP116152
Organism Escherichia coli strain DETEC-P61

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag PIC71_RS11830 Protein ID WP_000813794.1
Coordinates 2397111..2397287 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PIC71_RS11825 Protein ID WP_001270286.1
Coordinates 2396649..2397065 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC71_RS11805 (2391801) 2391801..2392742 - 942 WP_001251313.1 ABC transporter permease -
PIC71_RS11810 (2392743) 2392743..2393756 - 1014 WP_000220399.1 ABC transporter ATP-binding protein -
PIC71_RS11815 (2393774) 2393774..2394919 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
PIC71_RS11820 (2395164) 2395164..2396570 - 1407 WP_000760585.1 PLP-dependent aminotransferase family protein -
PIC71_RS11825 (2396649) 2396649..2397065 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
PIC71_RS11830 (2397111) 2397111..2397287 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
PIC71_RS11835 (2397509) 2397509..2397739 + 231 WP_000494244.1 YncJ family protein -
PIC71_RS11840 (2397831) 2397831..2399792 - 1962 WP_001301045.1 23S rRNA 5-hydroxycytidine C2501 synthase -
PIC71_RS11845 (2399865) 2399865..2400401 - 537 WP_063120676.1 DNA-binding transcriptional regulator SutR -
PIC71_RS11850 (2400493) 2400493..2401668 + 1176 WP_001236251.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2401708..2402973 1265


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T268188 WP_000813794.1 NZ_CP116152:c2397287-2397111 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT268188 WP_001270286.1 NZ_CP116152:c2397065-2396649 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References