Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2312260..2313848 Replicon chromosome
Accession NZ_CP116152
Organism Escherichia coli strain DETEC-P61

Toxin (Protein)


Gene name hipA Uniprot ID S1ELM3
Locus tag PIC71_RS11470 Protein ID WP_001125439.1
Coordinates 2312526..2313848 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag PIC71_RS11465 Protein ID WP_001301023.1
Coordinates 2312260..2312526 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC71_RS11465 (2312260) 2312260..2312526 + 267 WP_001301023.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
PIC71_RS11470 (2312526) 2312526..2313848 + 1323 WP_001125439.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
PIC71_RS11475 (2314226) 2314226..2315098 - 873 WP_072118989.1 methyl-accepting chemotaxis protein -
PIC71_RS11480 (2315157) 2315157..2315861 + 705 WP_001067855.1 IS6-like element IS26 family transposase -
PIC71_RS11485 (2315933) 2315933..2316280 - 348 WP_000679427.1 quaternary ammonium compound efflux SMR transporter QacE delta 1 -
PIC71_RS11490 (2316486) 2316486..2317274 - 789 WP_000503573.1 ANT(3'')-Ia family aminoglycoside nucleotidyltransferase AadA5 -
PIC71_RS11495 (2317405) 2317405..2317878 - 474 WP_001389366.1 trimethoprim-resistant dihydrofolate reductase DfrA17 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49275.82 Da        Isoelectric Point: 8.2482

>T268187 WP_001125439.1 NZ_CP116152:2312526-2313848 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVESNVLRLHGRLSREYGSK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10016.38 Da        Isoelectric Point: 6.2267

>AT268187 WP_001301023.1 NZ_CP116152:2312260-2312526 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDAKNASPES
TEQQNLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5K98
PDB 3TPV
PDB 3DNV
PDB 3TPD
PDB 3HZI
PDB 3FBR
PDB 4YG7
PDB 3TPE
PDB 2WIU
PDB 3DNT
PDB 3TPB
PDB 3TPT
PDB 3DNU

Antitoxin

Source ID Structure

References