Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4026303..4026921 Replicon chromosome
Accession NZ_CP116145
Organism Escherichia coli strain DETEC-P622

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag PIB88_RS19405 Protein ID WP_001291435.1
Coordinates 4026303..4026521 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag PIB88_RS19410 Protein ID WP_000344800.1
Coordinates 4026547..4026921 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIB88_RS19370 (4021590) 4021590..4022162 + 573 WP_000779831.1 YbaY family lipoprotein -
PIB88_RS19375 (4022193) 4022193..4022504 - 312 WP_000409908.1 MGMT family protein -
PIB88_RS19385 (4022883) 4022883..4023236 + 354 WP_000878135.1 DUF1428 family protein -
PIB88_RS19390 (4023278) 4023278..4024828 - 1551 WP_001385227.1 cyclic-guanylate-specific phosphodiesterase PdeB -
PIB88_RS19395 (4024992) 4024992..4025462 - 471 WP_000136192.1 YlaC family protein -
PIB88_RS19400 (4025578) 4025578..4026129 - 552 WP_000102539.1 maltose O-acetyltransferase -
PIB88_RS19405 (4026303) 4026303..4026521 - 219 WP_001291435.1 HHA domain-containing protein Toxin
PIB88_RS19410 (4026547) 4026547..4026921 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
PIB88_RS19415 (4027467) 4027467..4030616 - 3150 WP_271287807.1 efflux RND transporter permease AcrB -
PIB88_RS19420 (4030639) 4030639..4031832 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T268164 WP_001291435.1 NZ_CP116145:c4026521-4026303 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT268164 WP_000344800.1 NZ_CP116145:c4026921-4026547 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References