Detailed information of TA system TA268163

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3841148..3842837
• Replicon: chromosome
• Accession: NZ_CP116145
• Organism: Escherichia coli strain DETEC-P622

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: PIB88_RS18540
• Protein ID: WP_000365807.1
• Coordinates: 3841917..3842837 (+)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: PIB88_RS18535
• Protein ID: WP_001295795.1
• Coordinates: 3841148..3841930 (+)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PIB88_RS18530 (3837766)	3837766..3840864	-	3099	WP_000673070.1	type I restriction endonuclease	-
PIB88_RS18535 (3841148)	3841148..3841930	+	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
PIB88_RS18540 (3841917)	3841917..3842837	+	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
PIB88_RS18545 (3843002)	3843002..3843778	-	777	WP_000171155.1	site-specific integrase	-
PIB88_RS18550 (3843986)	3843986..3844321	-	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
PIB88_RS18555 (3844548)	3844548..3844706	-	159	Protein_3620	integrase	-
PIB88_RS18560 (3844755)	3844755..3844940	+	186	WP_000146240.1	hypothetical protein	-
PIB88_RS18565 (3845155)	3845155..3845769	+	615	WP_001019923.1	YagU family protein	-
PIB88_RS18570 (3845840)	3845840..3846006	+	167	Protein_3623	tail fiber assembly protein	-
PIB88_RS18575 (3846018)	3846018..3846347	-	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
PIB88_RS18580 (3846654)	3846654..3847364	-	711	WP_001295798.1	fimbrial chaperone EcpE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3834898..3845769	10871

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T268163 WP_000365807.1 NZ_CP116145:3841917-3842837 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT268163 WP_001295795.1 NZ_CP116145:3841148-3841930 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A061KTE0