Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 2355398..2356198 Replicon chromosome
Accession NZ_CP116145
Organism Escherichia coli strain DETEC-P622

Toxin (Protein)


Gene name ataT Uniprot ID F4T503
Locus tag PIB88_RS11465 Protein ID WP_000342452.1
Coordinates 2355398..2355925 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4T504
Locus tag PIB88_RS11470 Protein ID WP_001277107.1
Coordinates 2355932..2356198 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIB88_RS11440 (2350474) 2350474..2351241 - 768 WP_000082099.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
PIB88_RS11445 (2351238) 2351238..2352515 - 1278 WP_000803819.1 branched chain amino acid ABC transporter permease LivM -
PIB88_RS11450 (2352512) 2352512..2353438 - 927 WP_001295097.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
PIB88_RS11455 (2353486) 2353486..2354595 - 1110 WP_001296485.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
PIB88_RS11460 (2355018) 2355018..2355401 + 384 WP_000778796.1 aspartate 1-decarboxylase autocleavage activator PanM -
PIB88_RS11465 (2355398) 2355398..2355925 - 528 WP_000342452.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
PIB88_RS11470 (2355932) 2355932..2356198 - 267 WP_001277107.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
PIB88_RS11475 (2356347) 2356347..2357450 - 1104 WP_001021994.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
PIB88_RS11480 (2357721) 2357721..2358575 - 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
PIB88_RS11485 (2358820) 2358820..2359878 - 1059 WP_001042013.1 permease-like cell division protein FtsX -
PIB88_RS11490 (2359871) 2359871..2360539 - 669 WP_000617723.1 cell division ATP-binding protein FtsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19673.57 Da        Isoelectric Point: 6.6348

>T268156 WP_000342452.1 NZ_CP116145:c2355925-2355398 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTPDD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9929.38 Da        Isoelectric Point: 10.0863

>AT268156 WP_001277107.1 NZ_CP116145:c2356198-2355932 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILTEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061K5K9

Antitoxin

Source ID Structure
AlphaFold DB A0A061YQ57

References