Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1678798..1679452 Replicon chromosome
Accession NZ_CP116145
Organism Escherichia coli strain DETEC-P622

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag PIB88_RS08030 Protein ID WP_000244765.1
Coordinates 1678798..1679205 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag PIB88_RS08035 Protein ID WP_000354050.1
Coordinates 1679186..1679452 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIB88_RS08010 (1674755) 1674755..1676488 - 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -
PIB88_RS08015 (1676494) 1676494..1677204 - 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PIB88_RS08020 (1677229) 1677229..1678125 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
PIB88_RS08025 (1678237) 1678237..1678758 + 522 WP_001055874.1 flavodoxin FldB -
PIB88_RS08030 (1678798) 1678798..1679205 - 408 WP_000244765.1 protein YgfX Toxin
PIB88_RS08035 (1679186) 1679186..1679452 - 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
PIB88_RS08040 (1679695) 1679695..1680675 + 981 WP_000886084.1 tRNA-modifying protein YgfZ -
PIB88_RS08045 (1680752) 1680752..1681411 - 660 WP_000250275.1 hemolysin III family protein -
PIB88_RS08050 (1681575) 1681575..1681886 - 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
PIB88_RS08055 (1681931) 1681931..1683364 + 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T268152 WP_000244765.1 NZ_CP116145:c1679205-1678798 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT268152 WP_000354050.1 NZ_CP116145:c1679452-1679186 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References