Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4360977..4361572 Replicon chromosome
Accession NZ_CP116136
Organism Escherichia coli strain DETEC-P649

Toxin (Protein)


Gene name chpB Uniprot ID A0A0V9NWK6
Locus tag PIB66_RS20685 Protein ID WP_019842229.1
Coordinates 4360977..4361327 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag PIB66_RS20690 Protein ID WP_001223213.1
Coordinates 4361321..4361572 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIB66_RS20665 (4356307) 4356307..4357329 - 1023 WP_001550507.1 ABC transporter permease -
PIB66_RS20670 (4357343) 4357343..4358845 - 1503 WP_001550506.1 sugar ABC transporter ATP-binding protein -
PIB66_RS20675 (4358977) 4358977..4359933 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
PIB66_RS20680 (4360243) 4360243..4360773 + 531 WP_000055075.1 inorganic diphosphatase -
PIB66_RS20685 (4360977) 4360977..4361327 - 351 WP_019842229.1 endoribonuclease toxin ChpB Toxin
PIB66_RS20690 (4361321) 4361321..4361572 - 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
PIB66_RS20695 (4361784) 4361784..4362125 - 342 WP_001550504.1 gamma-glutamylcyclotransferase -
PIB66_RS20700 (4362128) 4362128..4365907 - 3780 WP_001596432.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-115)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12483.44 Da        Isoelectric Point: 5.6097

>T268137 WP_019842229.1 NZ_CP116136:c4361327-4360977 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVWMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT268137 WP_001223213.1 NZ_CP116136:c4361572-4361321 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V9NWK6

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References