Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4349315..4349837 Replicon chromosome
Accession NZ_CP116136
Organism Escherichia coli strain DETEC-P649

Toxin (Protein)


Gene name relE Uniprot ID A0A829L6G8
Locus tag PIB66_RS20625 Protein ID WP_001105433.1
Coordinates 4349315..4349605 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SC69
Locus tag PIB66_RS20630 Protein ID WP_000212715.1
Coordinates 4349595..4349837 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIB66_RS20610 (4344483) 4344483..4346138 + 1656 WP_001550509.1 alpha,alpha-phosphotrehalase -
PIB66_RS20615 (4346532) 4346532..4348670 + 2139 WP_000187798.1 anaerobic ribonucleoside-triphosphate reductase -
PIB66_RS20620 (4348850) 4348850..4349314 + 465 WP_001009182.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PIB66_RS20625 (4349315) 4349315..4349605 - 291 WP_001105433.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PIB66_RS20630 (4349595) 4349595..4349837 - 243 WP_000212715.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PIB66_RS20635 (4350029) 4350029..4350415 - 387 WP_001232246.1 cytochrome b562 -
PIB66_RS20640 (4350598) 4350598..4351950 - 1353 WP_001162173.1 metalloprotease PmbA -
PIB66_RS20645 (4352044) 4352044..4352595 + 552 WP_000166270.1 ribosome biogenesis factor YjgA -
PIB66_RS20650 (4352745) 4352745..4354118 - 1374 WP_001522402.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11367.23 Da        Isoelectric Point: 10.0238

>T268136 WP_001105433.1 NZ_CP116136:c4349605-4349315 [Escherichia coli]
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTQGYRLVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9125.56 Da        Isoelectric Point: 5.1369

>AT268136 WP_000212715.1 NZ_CP116136:c4349837-4349595 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829L6G8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H4B3

References