Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3674099..3674717 Replicon chromosome
Accession NZ_CP116136
Organism Escherichia coli strain DETEC-P649

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag PIB66_RS17505 Protein ID WP_001291435.1
Coordinates 3674499..3674717 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag PIB66_RS17500 Protein ID WP_000344800.1
Coordinates 3674099..3674473 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIB66_RS17490 (3669188) 3669188..3670381 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PIB66_RS17495 (3670404) 3670404..3673553 + 3150 WP_001132480.1 efflux RND transporter permease AcrB -
PIB66_RS17500 (3674099) 3674099..3674473 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
PIB66_RS17505 (3674499) 3674499..3674717 + 219 WP_001291435.1 HHA domain-containing protein Toxin
PIB66_RS17510 (3674889) 3674889..3675440 + 552 WP_000102564.1 maltose O-acetyltransferase -
PIB66_RS17515 (3675556) 3675556..3676026 + 471 WP_000136192.1 YlaC family protein -
PIB66_RS17520 (3676190) 3676190..3677740 + 1551 WP_001366446.1 cyclic-guanylate-specific phosphodiesterase PdeB -
PIB66_RS17525 (3677782) 3677782..3678135 - 354 WP_001550741.1 DUF1428 family protein -
PIB66_RS17535 (3678514) 3678514..3678825 + 312 WP_000409911.1 MGMT family protein -
PIB66_RS17540 (3678856) 3678856..3679428 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T268133 WP_001291435.1 NZ_CP116136:3674499-3674717 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT268133 WP_000344800.1 NZ_CP116136:3674099-3674473 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References