Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/UPF0150(antitoxin) |
| Location | 2622417..2623055 | Replicon | chromosome |
| Accession | NZ_CP116136 | ||
| Organism | Escherichia coli strain DETEC-P649 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | A0A7U9DHD1 |
| Locus tag | PIB66_RS12485 | Protein ID | WP_000813795.1 |
| Coordinates | 2622879..2623055 (-) | Length | 59 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | - |
| Locus tag | PIB66_RS12480 | Protein ID | WP_076797675.1 |
| Coordinates | 2622417..2622833 (-) | Length | 139 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PIB66_RS12460 (2617569) | 2617569..2618510 | - | 942 | WP_001251315.1 | ABC transporter permease | - |
| PIB66_RS12465 (2618511) | 2618511..2619524 | - | 1014 | WP_001551095.1 | ABC transporter ATP-binding protein | - |
| PIB66_RS12470 (2619542) | 2619542..2620687 | - | 1146 | WP_001551094.1 | ABC transporter substrate-binding protein | - |
| PIB66_RS12475 (2620932) | 2620932..2622338 | - | 1407 | WP_001551093.1 | PLP-dependent aminotransferase family protein | - |
| PIB66_RS12480 (2622417) | 2622417..2622833 | - | 417 | WP_076797675.1 | type II toxin-antitoxin system antitoxin HicB | Antitoxin |
| PIB66_RS12485 (2622879) | 2622879..2623055 | - | 177 | WP_000813795.1 | type II toxin-antitoxin system mRNA interferase toxin HicA | Toxin |
| PIB66_RS12490 (2623277) | 2623277..2623507 | + | 231 | WP_023910283.1 | YncJ family protein | - |
| PIB66_RS12495 (2623599) | 2623599..2625560 | - | 1962 | WP_001551090.1 | 23S rRNA 5-hydroxycytidine C2501 synthase | - |
| PIB66_RS12500 (2625633) | 2625633..2626169 | - | 537 | WP_001551089.1 | DNA-binding transcriptional regulator SutR | - |
| PIB66_RS12505 (2626261) | 2626261..2627433 | + | 1173 | WP_001551088.1 | BenE family transporter YdcO | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 59 a.a. Molecular weight: 6747.80 Da Isoelectric Point: 11.5666
>T268130 WP_000813795.1 NZ_CP116136:c2623055-2622879 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPSEEIKEPLRKAILKQLGLS
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPSEEIKEPLRKAILKQLGLS
Download Length: 177 bp
Antitoxin
Download Length: 139 a.a. Molecular weight: 15220.55 Da Isoelectric Point: 4.7386
>AT268130 WP_076797675.1 NZ_CP116136:c2622833-2622417 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPSNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPSNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV
Download Length: 417 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|