Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 198432..199044 Replicon chromosome
Accession NZ_CP116136
Organism Escherichia coli strain DETEC-P649

Toxin (Protein)


Gene name hicA Uniprot ID U9YXE2
Locus tag PIB66_RS00880 Protein ID WP_000833473.1
Coordinates 198432..198617 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID L4IWR9
Locus tag PIB66_RS00885 Protein ID WP_000499744.1
Coordinates 198634..199044 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIB66_RS00870 (195273) 195273..196424 + 1152 WP_000741501.1 L-threonine dehydrogenase -
PIB66_RS00875 (196625) 196625..198163 + 1539 WP_001551836.1 aldehyde dehydrogenase AldB -
PIB66_RS00880 (198432) 198432..198617 + 186 WP_000833473.1 type II toxin-antitoxin system HicA family toxin Toxin
PIB66_RS00885 (198634) 198634..199044 + 411 WP_000499744.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PIB66_RS00890 (199116) 199116..201080 - 1965 WP_001551835.1 glycoside hydrolase family 127 protein -
PIB66_RS00895 (201091) 201091..202491 - 1401 WP_000204811.1 MFS transporter -
PIB66_RS00900 (202717) 202717..203532 + 816 WP_000891823.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6800.89 Da        Isoelectric Point: 11.7053

>T268118 WP_000833473.1 NZ_CP116136:198432-198617 [Escherichia coli]
VKSADVIAILKQHGWEHIRTRGSHHQFRHPVHPGLVTVPHPKKDIKPGTLAQIGRQAGLTF

Download         Length: 186 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15241.15 Da        Isoelectric Point: 4.5486

>AT268118 WP_000499744.1 NZ_CP116136:198634-199044 [Escherichia coli]
MFYPAYIHSDPDGSASGFFPDVPGCYFAGDTLDNAFQDARSALVAHFETLCEMNEELPLPGSVETHLVQRAQDFIGGQWL
LVDINMNQFEGRAERINITMPKRLLNKIDTYVRNNPDYANRSAFLAEAARRVLPGV

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YXE2

Antitoxin

Source ID Structure
AlphaFold DB L4IWR9

References