Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3674090..3674708 Replicon chromosome
Accession NZ_CP116123
Organism Escherichia coli strain DETEC-P666

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag PIB57_RS17510 Protein ID WP_001291435.1
Coordinates 3674490..3674708 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag PIB57_RS17505 Protein ID WP_000344800.1
Coordinates 3674090..3674464 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIB57_RS17495 (3669179) 3669179..3670372 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PIB57_RS17500 (3670395) 3670395..3673544 + 3150 WP_001132480.1 efflux RND transporter permease AcrB -
PIB57_RS17505 (3674090) 3674090..3674464 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
PIB57_RS17510 (3674490) 3674490..3674708 + 219 WP_001291435.1 HHA domain-containing protein Toxin
PIB57_RS17515 (3674880) 3674880..3675431 + 552 WP_000102564.1 maltose O-acetyltransferase -
PIB57_RS17520 (3675547) 3675547..3676017 + 471 WP_000136192.1 YlaC family protein -
PIB57_RS17525 (3676181) 3676181..3677731 + 1551 WP_001366446.1 cyclic-guanylate-specific phosphodiesterase PdeB -
PIB57_RS17530 (3677773) 3677773..3678126 - 354 WP_001550741.1 DUF1428 family protein -
PIB57_RS17540 (3678505) 3678505..3678816 + 312 WP_000409911.1 MGMT family protein -
PIB57_RS17545 (3678847) 3678847..3679419 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T268100 WP_001291435.1 NZ_CP116123:3674490-3674708 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT268100 WP_000344800.1 NZ_CP116123:3674090-3674464 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References