Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3268196..3268901 Replicon chromosome
Accession NZ_CP116123
Organism Escherichia coli strain DETEC-P666

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag PIB57_RS15725 Protein ID WP_000539521.1
Coordinates 3268196..3268582 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag PIB57_RS15730 Protein ID WP_001280945.1
Coordinates 3268572..3268901 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIB57_RS15705 (3264200) 3264200..3264826 + 627 WP_001295292.1 glutathione S-transferase GstB -
PIB57_RS15710 (3264823) 3264823..3265938 - 1116 WP_000555051.1 aldose sugar dehydrogenase YliI -
PIB57_RS15715 (3266049) 3266049..3266432 - 384 WP_000497137.1 biofilm formation regulator BssR -
PIB57_RS15720 (3266645) 3266645..3267970 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
PIB57_RS15725 (3268196) 3268196..3268582 + 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PIB57_RS15730 (3268572) 3268572..3268901 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
PIB57_RS15735 (3268971) 3268971..3270299 - 1329 WP_001550887.1 GGDEF domain-containing protein -
PIB57_RS15740 (3270307) 3270307..3272655 - 2349 WP_001550886.1 EAL domain-containing protein -
PIB57_RS15745 (3272833) 3272833..3273744 - 912 WP_001236042.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T268099 WP_000539521.1 NZ_CP116123:3268196-3268582 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT268099 WP_001280945.1 NZ_CP116123:3268572-3268901 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References