Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 860221..861056 Replicon chromosome
Accession NZ_CP116123
Organism Escherichia coli strain DETEC-P666

Toxin (Protein)


Gene name yeeV Uniprot ID A0A2I6T1R7
Locus tag PIB57_RS04115 Protein ID WP_016231184.1
Coordinates 860221..860598 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7Z1I923
Locus tag PIB57_RS04120 Protein ID WP_016231183.1
Coordinates 860688..861056 (-) Length 123 a.a.

Genomic Context

PIB57_RS04155PIB57_RS04160PIB57_RS04085PIB57_RS04090PIB57_RS04095PIB57_RS04100PIB57_RS04105PIB57_RS04110PIB57_RS04115PIB57_RS04120PIB57_RS04125PIB57_RS04130PIB57_RS04135PIB57_RS04140PIB57_RS04145PIB57_RS04150
Location: 864322..864726 (405 bp)
Type: Others
Protein ID: WP_016231180.1
Location: 864723..865070 (348 bp)
Type: Others
Protein ID: WP_000612617.1
Location: 855335..856483 (1149 bp)
Type: Others
Protein ID: WP_000905926.1
Location: 856555..857538 (984 bp)
Type: Others
Protein ID: WP_001298261.1
Location: 858349..858519 (171 bp)
Type: Others
Protein ID: Protein_803
Location: 858861..859430 (570 bp)
Type: Others
Protein ID: WP_001290252.1
Location: 859527..859724 (198 bp)
Type: Others
Protein ID: WP_016231186.1
Location: 859736..860224 (489 bp)
Type: Others
Protein ID: WP_016231185.1
Location: 860221..860598 (378 bp)
Type: Toxin
Protein ID: WP_016231184.1
Location: 860688..861056 (369 bp)
Type: Antitoxin
Protein ID: WP_016231183.1
Location: 861106..861750 (645 bp)
Type: Others
Protein ID: Protein_809
Location: 861769..861990 (222 bp)
Type: Others
Protein ID: WP_016231182.1
Location: 862053..862529 (477 bp)
Type: Others
Protein ID: WP_001186774.1
Location: 862545..863030 (486 bp)
Type: Others
Protein ID: WP_000849596.1
Location: 863085..863903 (819 bp)
Type: Others
Protein ID: WP_023909039.1
Location: 864003..864236 (234 bp)
Type: Others
Protein ID: WP_001119719.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
PIB57_RS04085 (855335)855335..856483-1149WP_000905926.1capsule polysaccharide export inner-membrane protein KpsE-
PIB57_RS04090 (856555)856555..857538-984WP_001298261.1KpsF/GutQ family sugar-phosphate isomerase-
PIB57_RS04095 (858349)858349..858519-171Protein_803IS110 family transposase-
PIB57_RS04100 (858861)858861..859430-570WP_001290252.1DUF4942 domain-containing protein-
PIB57_RS04105 (859527)859527..859724-198WP_016231186.1DUF957 domain-containing protein-
PIB57_RS04110 (859736)859736..860224-489WP_016231185.1DUF5983 family protein-
PIB57_RS04115 (860221)860221..860598-378WP_016231184.1TA system toxin CbtA family proteinToxin
PIB57_RS04120 (860688)860688..861056-369WP_016231183.1type IV toxin-antitoxin system YeeU family antitoxinAntitoxin
PIB57_RS04125 (861106)861106..861750-645Protein_809antitoxin of toxin-antitoxin stability system-
PIB57_RS04130 (861769)861769..861990-222WP_016231182.1DUF987 domain-containing protein-
PIB57_RS04135 (862053)862053..862529-477WP_001186774.1RadC family protein-
PIB57_RS04140 (862545)862545..863030-486WP_000849596.1antirestriction protein-
PIB57_RS04145 (863085)863085..863903-819WP_023909039.1DUF932 domain-containing protein-
PIB57_RS04150 (864003)864003..864236-234WP_001119719.1DUF905 family protein-
PIB57_RS04155 (864322)864322..864726+405WP_016231180.1transposase-
PIB57_RS04160 (864723)864723..865070+348WP_000612617.1IS66 family insertion sequence element accessory protein TnpB-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14106.07 Da        Isoelectric Point: 8.2905

>T268088 WP_016231184.1 NZ_CP116123:c860598-860221 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ

Download         Length: 378 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13613.43 Da        Isoelectric Point: 6.8413

>AT268088 WP_016231183.1 NZ_CP116123:c861056-860688 [Escherichia coli]
MSDTLPGTTLPDNNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADANHLDQAFPLLMKQLELMFTSS
ELNPHRQNTVTLYAKGLTCHADTLGSCGYVYLAVYPTPETKQ

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A2I6T1R7

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A7Z1I923

References