Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 72580..73414 Replicon chromosome
Accession NZ_CP116123
Organism Escherichia coli strain DETEC-P666

Toxin (Protein)


Gene name yeeV Uniprot ID A0A4S3WCD6
Locus tag PIB57_RS00315 Protein ID WP_021566610.1
Coordinates 72580..72957 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag PIB57_RS00320 Protein ID WP_001285585.1
Coordinates 73046..73414 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIB57_RS00285 (67947) 67947..68870 - 924 WP_000535949.1 carboxylate/amino acid/amine transporter -
PIB57_RS00290 (68981) 68981..70165 - 1185 WP_001172876.1 sugar efflux transporter -
PIB57_RS00295 (70570) 70570..70775 - 206 Protein_58 RhuM family protein -
PIB57_RS00300 (70956) 70956..71801 - 846 WP_021566612.1 DUF4942 domain-containing protein -
PIB57_RS00305 (71886) 71886..72083 - 198 WP_000839269.1 DUF957 domain-containing protein -
PIB57_RS00310 (72095) 72095..72583 - 489 WP_048237286.1 DUF5983 family protein -
PIB57_RS00315 (72580) 72580..72957 - 378 WP_021566610.1 TA system toxin CbtA family protein Toxin
PIB57_RS00320 (73046) 73046..73414 - 369 WP_001285585.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
PIB57_RS00325 (73488) 73488..73709 - 222 WP_000692323.1 DUF987 domain-containing protein -
PIB57_RS00330 (73772) 73772..74248 - 477 WP_001186726.1 RadC family protein -
PIB57_RS00335 (74264) 74264..74743 - 480 WP_048265132.1 antirestriction protein -
PIB57_RS00340 (74825) 74825..75643 - 819 WP_001234629.1 DUF932 domain-containing protein -
PIB57_RS00345 (75743) 75743..75976 - 234 WP_001119729.1 DUF905 family protein -
PIB57_RS00350 (76055) 76055..76509 - 455 Protein_69 IrmA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14058.02 Da        Isoelectric Point: 7.8276

>T268084 WP_021566610.1 NZ_CP116123:c72957-72580 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT268084 WP_001285585.1 NZ_CP116123:c73414-73046 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S3WCD6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References