Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 55076..55719 Replicon plasmid pDETEC15
Accession NZ_CP116118
Organism Escherichia coli strain DETEC-P793

Toxin (Protein)


Gene name vagD Uniprot ID V0UN72
Locus tag PIC92_RS26435 Protein ID WP_001034044.1
Coordinates 55303..55719 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B1P7N7
Locus tag PIC92_RS26430 Protein ID WP_001261286.1
Coordinates 55076..55306 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC92_RS26415 (PIC92_26420) 50213..50443 + 231 WP_001261278.1 type II toxin-antitoxin system VapB family antitoxin -
PIC92_RS26420 (PIC92_26425) 50440..50856 + 417 WP_001034046.1 type II toxin-antitoxin system VapC family toxin -
PIC92_RS26425 (PIC92_26430) 50901..54695 - 3795 WP_001144732.1 hypothetical protein -
PIC92_RS26430 (PIC92_26435) 55076..55306 + 231 WP_001261286.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
PIC92_RS26435 (PIC92_26440) 55303..55719 + 417 WP_001034044.1 type II toxin-antitoxin system VapC family toxin Toxin
PIC92_RS26440 (PIC92_26445) 55794..57359 + 1566 WP_001128474.1 AAA family ATPase -
PIC92_RS26445 (PIC92_26450) 57344..58366 + 1023 WP_000361402.1 helicase UvrD -
PIC92_RS26455 (PIC92_26460) 59620..60317 + 698 WP_223155668.1 IS1-like element IS1A family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - senB 1..82761 82761


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15232.66 Da        Isoelectric Point: 6.8536

>T268083 WP_001034044.1 NZ_CP116118:55303-55719 [Escherichia coli]
VNKIYMLDTNICSFIMREQPEALLKHLEQSVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCERLDAVLPWDRA
AVDATTEIKVALRLAGTPIGPNDTAIAGHAIAACAILVTNNVREFERVPGLVLEDWVR

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8747.86 Da        Isoelectric Point: 4.3775

>AT268083 WP_001261286.1 NZ_CP116118:55076-55306 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLELEKADPDFMTEREDVVSDEGRVNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CHW1

Antitoxin

Source ID Structure
AlphaFold DB A0A829CKZ6

References