Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/ElaA-DUF1778
Location 41064..41824 Replicon plasmid pDETEC13
Accession NZ_CP116116
Organism Escherichia coli strain DETEC-P793

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag PIC92_RS24800 Protein ID WP_271293057.1
Coordinates 41339..41824 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag PIC92_RS24795 Protein ID WP_271293067.1
Coordinates 41064..41351 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC92_RS24770 (PIC92_24770) 36143..37512 + 1370 WP_271293055.1 IS3 family transposase -
PIC92_RS24775 (PIC92_24775) 37670..39094 - 1425 WP_105667421.1 MFS transporter -
PIC92_RS24780 (PIC92_24780) 39205..39765 + 561 WP_271293056.1 MarR family transcriptional regulator -
PIC92_RS24785 (PIC92_24785) 39709..40683 - 975 WP_012478345.1 IS30-like element ISApl1 family transposase -
PIC92_RS24790 (PIC92_24790) 40763..40939 + 177 Protein_52 MarR family transcriptional regulator -
PIC92_RS24795 (PIC92_24795) 41064..41351 + 288 WP_271293067.1 DUF1778 domain-containing protein Antitoxin
PIC92_RS24800 (PIC92_24800) 41339..41824 + 486 WP_271293057.1 GNAT family N-acetyltransferase Toxin
PIC92_RS24805 (PIC92_24805) 42104..42256 + 153 Protein_55 DUF5431 family protein -
PIC92_RS24810 (PIC92_24810) 42201..42323 + 123 WP_085842394.1 Hok/Gef family protein -
PIC92_RS24815 (PIC92_24815) 42928..43902 + 975 WP_207304325.1 Hok/Gef family protein -
PIC92_RS24820 (PIC92_24820) 43886..44008 + 123 WP_254911979.1 hypothetical protein -
PIC92_RS24825 (PIC92_24825) 44100..44444 - 345 WP_223383365.1 phosphonate ABC transporter substrate-binding protein -
PIC92_RS24830 (PIC92_24830) 44708..45004 + 297 WP_271293058.1 hydrogenase expression/formation protein HypD -
PIC92_RS24835 (PIC92_24835) 45073..46140 + 1068 WP_064190237.1 hypothetical protein -
PIC92_RS24840 (PIC92_24840) 46251..46751 - 501 WP_064190236.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pla 1..209927 209927


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(29-152)

Antitoxin

Vibrio phage ICP1, Orf50

(13-89)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17680.47 Da        Isoelectric Point: 9.8566

>T268076 WP_271293057.1 NZ_CP116116:41339-41824 [Escherichia coli]
VGCVTAPEPLSAFHQVAEFVSGETVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PNPIPVIILARLAVDLSFRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQTQQRTLFLKLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11089.73 Da        Isoelectric Point: 4.4237

>AT268076 WP_271293067.1 NZ_CP116116:41064-41351 [Escherichia coli]
MLYKEYLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVTDD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References