Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 32989..33899 | Replicon | plasmid pDETEC13 |
| Accession | NZ_CP116116 | ||
| Organism | Escherichia coli strain DETEC-P793 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A663AYG0 |
| Locus tag | PIC92_RS24750 | Protein ID | WP_004026354.1 |
| Coordinates | 33429..33899 (+) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A6P1V3Q9 |
| Locus tag | PIC92_RS24745 | Protein ID | WP_004026357.1 |
| Coordinates | 32989..33432 (+) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PIC92_RS24730 (PIC92_24730) | 28619..29650 | + | 1032 | WP_004026364.1 | hypothetical protein | - |
| PIC92_RS24735 (PIC92_24735) | 31195..31617 | + | 423 | WP_004181893.1 | translesion error-prone DNA polymerase V autoproteolytic subunit | - |
| PIC92_RS24740 (PIC92_24740) | 31617..32888 | + | 1272 | WP_004181894.1 | translesion error-prone DNA polymerase V subunit UmuC | - |
| PIC92_RS24745 (PIC92_24745) | 32989..33432 | + | 444 | WP_004026357.1 | DUF2384 domain-containing protein | Antitoxin |
| PIC92_RS24750 (PIC92_24750) | 33429..33899 | + | 471 | WP_004026354.1 | RES family NAD+ phosphorylase | Toxin |
| PIC92_RS24755 (PIC92_24755) | 34354..34542 | - | 189 | WP_024198076.1 | hypothetical protein | - |
| PIC92_RS24760 (PIC92_24760) | 35154..35414 | - | 261 | WP_004026352.1 | hypothetical protein | - |
| PIC92_RS24765 (PIC92_24765) | 35589..35744 | + | 156 | WP_271293054.1 | hypothetical protein | - |
| PIC92_RS24770 (PIC92_24770) | 36143..37512 | + | 1370 | WP_271293055.1 | IS3 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | pla | 1..209927 | 209927 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17515.79 Da Isoelectric Point: 4.6155
>T268075 WP_004026354.1 NZ_CP116116:33429-33899 [Escherichia coli]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
Antitoxin
Download Length: 148 a.a. Molecular weight: 16480.80 Da Isoelectric Point: 10.2498
>AT268075 WP_004026357.1 NZ_CP116116:32989-33432 [Escherichia coli]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A663AYG0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6P1V3Q9 |