Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3827828..3828482 Replicon chromosome
Accession NZ_CP116115
Organism Escherichia coli strain DETEC-P793

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag PIC92_RS18750 Protein ID WP_000244781.1
Coordinates 3827828..3828235 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag PIC92_RS18755 Protein ID WP_000354046.1
Coordinates 3828216..3828482 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC92_RS18730 (3823785) 3823785..3825518 - 1734 WP_000813189.1 single-stranded-DNA-specific exonuclease RecJ -
PIC92_RS18735 (3825524) 3825524..3826234 - 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PIC92_RS18740 (3826259) 3826259..3827155 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
PIC92_RS18745 (3827267) 3827267..3827788 + 522 WP_001055874.1 flavodoxin FldB -
PIC92_RS18750 (3827828) 3827828..3828235 - 408 WP_000244781.1 protein YgfX Toxin
PIC92_RS18755 (3828216) 3828216..3828482 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
PIC92_RS18760 (3828725) 3828725..3829705 + 981 WP_000886078.1 tRNA-modifying protein YgfZ -
PIC92_RS18765 (3829782) 3829782..3830441 - 660 WP_000250274.1 hemolysin III family protein -
PIC92_RS18770 (3830605) 3830605..3830916 - 312 WP_001182959.1 N(4)-acetylcytidine aminohydrolase -
PIC92_RS18775 (3830961) 3830961..3832394 + 1434 WP_001339296.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T268071 WP_000244781.1 NZ_CP116115:c3828235-3827828 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT268071 WP_000354046.1 NZ_CP116115:c3828482-3828216 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References