Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 3672011..3672594 Replicon chromosome
Accession NZ_CP116115
Organism Escherichia coli strain DETEC-P793

Toxin (Protein)


Gene name mazF Uniprot ID S1PVD8
Locus tag PIC92_RS18125 Protein ID WP_000254749.1
Coordinates 3672011..3672346 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID S1P3W5
Locus tag PIC92_RS18130 Protein ID WP_000581937.1
Coordinates 3672346..3672594 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC92_RS18110 (3667897) 3667897..3669195 - 1299 WP_000036723.1 phosphopyruvate hydratase -
PIC92_RS18115 (3669283) 3669283..3670920 - 1638 WP_001774030.1 CTP synthase (glutamine hydrolyzing) -
PIC92_RS18120 (3671148) 3671148..3671939 - 792 WP_001071648.1 nucleoside triphosphate pyrophosphohydrolase -
PIC92_RS18125 (3672011) 3672011..3672346 - 336 WP_000254749.1 endoribonuclease MazF Toxin
PIC92_RS18130 (3672346) 3672346..3672594 - 249 WP_000581937.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
PIC92_RS18135 (3672672) 3672672..3674906 - 2235 WP_000226797.1 GTP diphosphokinase -
PIC92_RS18140 (3674954) 3674954..3676255 - 1302 WP_000046817.1 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12137.06 Da        Isoelectric Point: 8.7218

>T268070 WP_000254749.1 NZ_CP116115:c3672346-3672011 [Escherichia coli]
MVSRYVPDTGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKR
IAWRARGATKKGTVAPEELQLIKAKINVLIG

Download         Length: 336 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9355.74 Da        Isoelectric Point: 4.4665

>AT268070 WP_000581937.1 NZ_CP116115:c3672594-3672346 [Escherichia coli]
MIHSSVKRWGNSPAVRIPATLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGEPKDKE
VW

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PVD8

Antitoxin

Source ID Structure
PDB 1UB4
PDB 5CQX
PDB 5CQY
PDB 1MVF
PDB 2MRN
PDB 2MRU
AlphaFold DB A0A7U9LMB4

References