Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1219391..1220009 Replicon chromosome
Accession NZ_CP116115
Organism Escherichia coli strain DETEC-P793

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag PIC92_RS05875 Protein ID WP_001291435.1
Coordinates 1219391..1219609 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag PIC92_RS05880 Protein ID WP_000344800.1
Coordinates 1219635..1220009 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC92_RS05840 (1214679) 1214679..1215251 + 573 WP_000779831.1 YbaY family lipoprotein -
PIC92_RS05845 (1215282) 1215282..1215593 - 312 WP_000409908.1 MGMT family protein -
PIC92_RS05855 (1215972) 1215972..1216325 + 354 WP_000878140.1 DUF1428 domain-containing protein -
PIC92_RS05860 (1216367) 1216367..1217917 - 1551 WP_001538392.1 cyclic-guanylate-specific phosphodiesterase PdeB -
PIC92_RS05865 (1218081) 1218081..1218551 - 471 WP_000136192.1 YlaC family protein -
PIC92_RS05870 (1218667) 1218667..1219218 - 552 WP_000102539.1 maltose O-acetyltransferase -
PIC92_RS05875 (1219391) 1219391..1219609 - 219 WP_001291435.1 HHA domain-containing protein Toxin
PIC92_RS05880 (1219635) 1219635..1220009 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
PIC92_RS05885 (1220555) 1220555..1223704 - 3150 WP_001132480.1 efflux RND transporter permease AcrB -
PIC92_RS05890 (1223727) 1223727..1224920 - 1194 WP_001538394.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T268062 WP_001291435.1 NZ_CP116115:c1219609-1219391 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT268062 WP_000344800.1 NZ_CP116115:c1220009-1219635 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References