Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 316488..317320 Replicon chromosome
Accession NZ_CP116115
Organism Escherichia coli strain DETEC-P793

Toxin (Protein)


Gene name yeeV Uniprot ID S1PD64
Locus tag PIC92_RS01445 Protein ID WP_000854753.1
Coordinates 316488..316862 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NQ68
Locus tag PIC92_RS01450 Protein ID WP_001540478.1
Coordinates 316952..317320 (-) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC92_RS01425 (312841) 312841..314379 - 1539 WP_001187191.1 lysine decarboxylation/transport transcriptional activator CadC -
PIC92_RS01430 (315128) 315128..315697 - 570 WP_001560692.1 DUF4942 domain-containing protein -
PIC92_RS01435 (315794) 315794..315991 - 198 WP_000839281.1 DUF957 domain-containing protein -
PIC92_RS01440 (316003) 316003..316491 - 489 WP_000777545.1 DUF5983 family protein -
PIC92_RS01445 (316488) 316488..316862 - 375 WP_000854753.1 TA system toxin CbtA family protein Toxin
PIC92_RS01450 (316952) 316952..317320 - 369 WP_001540478.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
PIC92_RS01455 (317483) 317483..317704 - 222 WP_000692311.1 DUF987 domain-containing protein -
PIC92_RS01460 (317767) 317767..318243 - 477 WP_001186786.1 RadC family protein -
PIC92_RS01465 (318259) 318259..318744 - 486 WP_000214398.1 antirestriction protein -
PIC92_RS01470 (318835) 318835..319653 - 819 WP_001773857.1 DUF932 domain-containing protein -
PIC92_RS01475 (319743) 319743..319976 - 234 WP_001278283.1 DUF905 family protein -
PIC92_RS01480 (319982) 319982..320659 - 678 WP_001097301.1 hypothetical protein -
PIC92_RS01485 (320807) 320807..321487 - 681 WP_001282919.1 WYL domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 305028..362652 57624


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 125 a.a.        Molecular weight: 14005.00 Da        Isoelectric Point: 8.2905

>T268053 WP_000854753.1 NZ_CP116115:c316862-316488 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp


Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13652.53 Da        Isoelectric Point: 7.8398

>AT268053 WP_001540478.1 NZ_CP116115:c317320-316952 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7U9LVU0


Antitoxin

Source ID Structure
AlphaFold DB S1NQ68

References