Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 305028..305525 Replicon chromosome
Accession NZ_CP116115
Organism Escherichia coli strain DETEC-P793

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag PIC92_RS01400 Protein ID WP_001173343.1
Coordinates 305352..305525 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID S1NQ59
Locus tag PIC92_RS01395 Protein ID WP_001312331.1
Coordinates 305028..305324 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC92_RS01375 (301757) 301757..302476 - 720 WP_001540474.1 two-component system response regulator DcuR -
PIC92_RS01380 (302473) 302473..304104 - 1632 WP_001216482.1 sensor histidine kinase -
PIC92_RS01385 (304285) 304285..304515 + 231 WP_000373293.1 4Fe-4S mono-cluster protein YjdI -
PIC92_RS01390 (304527) 304527..304799 + 273 WP_000405647.1 GNAT family N-acetyltransferase -
PIC92_RS01395 (305028) 305028..305324 + 297 WP_001312331.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
PIC92_RS01400 (305352) 305352..305525 + 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
PIC92_RS01405 (305644) 305644..307161 - 1518 WP_000003806.1 lysine--tRNA ligase -
PIC92_RS01410 (307398) 307398..308855 - 1458 WP_000856826.1 dipeptide/tripeptide permease DtpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 305028..362652 57624


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T268052 WP_001173343.1 NZ_CP116115:305352-305525 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11440.95 Da        Isoelectric Point: 4.1705

>AT268052 WP_001312331.1 NZ_CP116115:305028-305324 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLSIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB S1NQ59

References