Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pezAT/zeta-HTH_XRE |
| Location | 462658..463958 | Replicon | chromosome |
| Accession | NC_017456 | ||
| Organism | Gardnerella vaginalis HMP9231 | ||
Toxin (Protein)
| Gene name | pezT | Uniprot ID | - |
| Locus tag | HMPREF9231_RS01775 | Protein ID | WP_004574874.1 |
| Coordinates | 463149..463958 (+) | Length | 270 a.a. |
Antitoxin (Protein)
| Gene name | pezT | Uniprot ID | S4HGB9 |
| Locus tag | HMPREF9231_RS01770 | Protein ID | WP_004113003.1 |
| Coordinates | 462658..463131 (+) | Length | 158 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HMPREF9231_RS01760 | 458812..459822 | - | 1011 | WP_004114525.1 | UDP-glucose 4-epimerase GalE | - |
| HMPREF9231_RS01765 | 460690..462120 | + | 1431 | WP_004114528.1 | hypothetical protein | - |
| HMPREF9231_RS01770 | 462658..463131 | + | 474 | WP_004113003.1 | helix-turn-helix domain-containing protein | Antitoxin |
| HMPREF9231_RS01775 | 463149..463958 | + | 810 | WP_004574874.1 | zeta toxin family protein | Toxin |
| HMPREF9231_RS01780 | 464467..465426 | - | 960 | WP_004112999.1 | aldose 1-epimerase family protein | - |
| HMPREF9231_RS01785 | 465474..465974 | - | 501 | WP_004112997.1 | Cys-tRNA(Pro) deacylase | - |
| HMPREF9231_RS01790 | 466084..467139 | - | 1056 | WP_004112995.1 | type I glyceraldehyde-3-phosphate dehydrogenase | - |
| HMPREF9231_RS01795 | 467315..468052 | - | 738 | WP_004112993.1 | thiamine diphosphokinase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 270 a.a. Molecular weight: 30918.69 Da Isoelectric Point: 8.9574
>T26805 WP_004574874.1 NC_017456:463149-463958 [Gardnerella vaginalis HMP9231]
MGKCDFAMVIEDFSEEYFTHCLLRNLRSLQMYKHADLHPKAVLLGGQSGAGKTTIHVIKQKEFNGNIIILDADSYRTQHP
YYCELLDKYGKESVKYTSAFSAKMVRSLIDELSSKKYNLIIEGTLRSVEVPSSTAKMLIDRGYRVSLAVIATKPELSWIS
TLIRYREMYLEDPKSARATPKDHHDNIVNNIVDNLLKLEQSKIFDRIQIYKRDEKCIYDSDSYKNNPNITAASVLKEVLF
GKKTIDEKKLICHAKNRLNELDKLIDKSL
MGKCDFAMVIEDFSEEYFTHCLLRNLRSLQMYKHADLHPKAVLLGGQSGAGKTTIHVIKQKEFNGNIIILDADSYRTQHP
YYCELLDKYGKESVKYTSAFSAKMVRSLIDELSSKKYNLIIEGTLRSVEVPSSTAKMLIDRGYRVSLAVIATKPELSWIS
TLIRYREMYLEDPKSARATPKDHHDNIVNNIVDNLLKLEQSKIFDRIQIYKRDEKCIYDSDSYKNNPNITAASVLKEVLF
GKKTIDEKKLICHAKNRLNELDKLIDKSL
Download Length: 810 bp
>T26805 NC_017456:463149-463958 [Gardnerella vaginalis HMP9231]
ATGGGTAAGTGTGATTTTGCTATGGTTATAGAAGATTTTAGCGAAGAGTATTTTACTCACTGTTTGTTAAGAAATTTACG
TTCTTTACAAATGTATAAGCATGCAGATTTGCATCCTAAGGCGGTTTTACTCGGTGGTCAAAGTGGTGCTGGCAAAACGA
CCATTCATGTAATAAAACAAAAAGAATTTAACGGTAACATAATAATCCTTGATGCTGATAGCTATAGGACTCAACACCCT
TATTATTGCGAGTTGCTTGATAAATACGGTAAAGAAAGTGTTAAATATACGAGTGCTTTTTCAGCAAAAATGGTGAGAAG
CTTAATTGATGAGTTAAGTTCTAAAAAATATAATCTCATAATTGAAGGTACTTTGCGCAGTGTTGAAGTTCCTAGTAGTA
CTGCGAAAATGTTGATAGATCGTGGTTACCGTGTTTCTCTTGCTGTCATTGCAACAAAACCTGAATTGTCATGGATCAGT
ACGCTGATTCGCTACAGGGAAATGTATTTGGAAGATCCTAAAAGTGCTAGGGCAACTCCTAAGGATCATCACGACAATAT
TGTGAACAATATAGTAGATAACTTGTTGAAATTAGAACAATCGAAAATATTTGACAGAATTCAGATTTACAAGCGAGACG
AAAAATGTATATATGATTCTGATTCGTATAAAAATAATCCAAATATTACAGCAGCTAGTGTTCTTAAGGAAGTGCTCTTT
GGTAAGAAAACTATTGATGAGAAAAAGTTGATTTGCCACGCTAAGAATAGGTTGAATGAACTAGACAAGTTGATAGATAA
AAGTTTGTAG
ATGGGTAAGTGTGATTTTGCTATGGTTATAGAAGATTTTAGCGAAGAGTATTTTACTCACTGTTTGTTAAGAAATTTACG
TTCTTTACAAATGTATAAGCATGCAGATTTGCATCCTAAGGCGGTTTTACTCGGTGGTCAAAGTGGTGCTGGCAAAACGA
CCATTCATGTAATAAAACAAAAAGAATTTAACGGTAACATAATAATCCTTGATGCTGATAGCTATAGGACTCAACACCCT
TATTATTGCGAGTTGCTTGATAAATACGGTAAAGAAAGTGTTAAATATACGAGTGCTTTTTCAGCAAAAATGGTGAGAAG
CTTAATTGATGAGTTAAGTTCTAAAAAATATAATCTCATAATTGAAGGTACTTTGCGCAGTGTTGAAGTTCCTAGTAGTA
CTGCGAAAATGTTGATAGATCGTGGTTACCGTGTTTCTCTTGCTGTCATTGCAACAAAACCTGAATTGTCATGGATCAGT
ACGCTGATTCGCTACAGGGAAATGTATTTGGAAGATCCTAAAAGTGCTAGGGCAACTCCTAAGGATCATCACGACAATAT
TGTGAACAATATAGTAGATAACTTGTTGAAATTAGAACAATCGAAAATATTTGACAGAATTCAGATTTACAAGCGAGACG
AAAAATGTATATATGATTCTGATTCGTATAAAAATAATCCAAATATTACAGCAGCTAGTGTTCTTAAGGAAGTGCTCTTT
GGTAAGAAAACTATTGATGAGAAAAAGTTGATTTGCCACGCTAAGAATAGGTTGAATGAACTAGACAAGTTGATAGATAA
AAGTTTGTAG
Antitoxin
Download Length: 158 a.a. Molecular weight: 18016.48 Da Isoelectric Point: 5.3394
>AT26805 WP_004113003.1 NC_017456:462658-463131 [Gardnerella vaginalis HMP9231]
MVSVNIRALRRSKKITQQELAEALGVSRNSIVRYENGTSAISTRLIDKICDKFKVSLFDIVHEKELSASDKYDLNMKIEV
LKERGALLLARLYKYEDSMNIQFDDSSNAWIAISDDLSDVINTKIYTSTNFEDINRYIGYLDGIERLLEYVSCNKNS
MVSVNIRALRRSKKITQQELAEALGVSRNSIVRYENGTSAISTRLIDKICDKFKVSLFDIVHEKELSASDKYDLNMKIEV
LKERGALLLARLYKYEDSMNIQFDDSSNAWIAISDDLSDVINTKIYTSTNFEDINRYIGYLDGIERLLEYVSCNKNS
Download Length: 474 bp
>AT26805 NC_017456:462658-463131 [Gardnerella vaginalis HMP9231]
ATGGTTTCTGTGAATATTCGAGCACTACGTCGCTCAAAAAAAATAACTCAACAAGAGTTAGCTGAAGCATTAGGAGTATC
TCGTAATAGCATTGTGCGATACGAAAATGGTACAAGTGCTATTTCAACTAGGTTAATAGATAAGATTTGTGATAAATTCA
AGGTTTCTCTTTTTGATATCGTACATGAAAAAGAATTATCTGCATCTGATAAATACGATTTGAATATGAAGATTGAAGTT
TTAAAGGAGCGTGGCGCACTTTTACTGGCTCGTTTATATAAATACGAGGATAGTATGAATATACAATTTGATGATTCTTC
TAATGCATGGATTGCAATTAGTGATGATTTATCAGATGTAATTAATACAAAGATTTATACATCTACAAATTTTGAAGATA
TAAATCGTTATATCGGATATTTAGATGGCATAGAACGCTTGCTTGAATACGTAAGTTGCAATAAAAATAGTTAA
ATGGTTTCTGTGAATATTCGAGCACTACGTCGCTCAAAAAAAATAACTCAACAAGAGTTAGCTGAAGCATTAGGAGTATC
TCGTAATAGCATTGTGCGATACGAAAATGGTACAAGTGCTATTTCAACTAGGTTAATAGATAAGATTTGTGATAAATTCA
AGGTTTCTCTTTTTGATATCGTACATGAAAAAGAATTATCTGCATCTGATAAATACGATTTGAATATGAAGATTGAAGTT
TTAAAGGAGCGTGGCGCACTTTTACTGGCTCGTTTATATAAATACGAGGATAGTATGAATATACAATTTGATGATTCTTC
TAATGCATGGATTGCAATTAGTGATGATTTATCAGATGTAATTAATACAAAGATTTATACATCTACAAATTTTGAAGATA
TAAATCGTTATATCGGATATTTAGATGGCATAGAACGCTTGCTTGAATACGTAAGTTGCAATAAAAATAGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|