Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 87890..88515 Replicon plasmid pDETEC19
Accession NZ_CP116111
Organism Escherichia coli strain DETEC-P80

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PIC84_RS23390 Protein ID WP_000911313.1
Coordinates 88117..88515 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID V0VCB2
Locus tag PIC84_RS23385 Protein ID WP_000450520.1
Coordinates 87890..88117 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC84_RS23385 (87890) 87890..88117 + 228 WP_000450520.1 toxin-antitoxin system antitoxin VapB Antitoxin
PIC84_RS23390 (88117) 88117..88515 + 399 WP_000911313.1 type II toxin-antitoxin system VapC family toxin Toxin
PIC84_RS23395 (88524) 88524..90677 - 2154 WP_000009324.1 type IV conjugative transfer system coupling protein TraD -
PIC84_RS23400 (90930) 90930..91661 - 732 WP_023565183.1 conjugal transfer complement resistance protein TraT -
PIC84_RS23405 (91693) 91693..92190 - 498 WP_000605857.1 entry exclusion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid tet(A) / oqxA / oqxB / aac(3)-IIa / mph(A) / sul1 / qacE / aadA5 / blaTEM-1B / sitABCD iroB / iroC / iroD / iroE / iroN / iutA / iucD / iucC / iucB / iucA 1..159559 159559


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-50)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14901.15 Da        Isoelectric Point: 7.8605

>T268041 WP_000911313.1 NZ_CP116111:88117-88515 [Escherichia coli]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHS
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVDGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8596.63 Da        Isoelectric Point: 4.7513

>AT268041 WP_000450520.1 NZ_CP116111:87890-88117 [Escherichia coli]
METTVFFSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGHNVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V0VCB2

References