Detailed information of TA system TA026804

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2610697..2611325
• Replicon: chromosome
• Accession: NC_017454
• Organism: Geobacter sulfurreducens KN400

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q74AB8
• Locus tag: KN400_RS13065
• Protein ID: WP_010943110.1
• Coordinates: 2610697..2611098 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: Q74AB7
• Locus tag: KN400_RS13070
• Protein ID: WP_010943111.1
• Coordinates: 2611098..2611325 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KN400_RS13050	2606699..2608072	-	1374	WP_010943105.1	integron integrase	-
KN400_RS13055	2608153..2608503	+	351	WP_010943106.1	hypothetical protein	-
KN400_RS19575	2608648..2609178	+	531	WP_014551838.1	uracil-DNA glycosylase superfamily protein	-
KN400_RS13060	2609242..2610627	+	1386	WP_014551839.1	ATPase AAA	-
KN400_RS13065	2610697..2611098	-	402	WP_010943110.1	type II toxin-antitoxin system VapC family toxin	Toxin
KN400_RS13070	2611098..2611325	-	228	WP_010943111.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
KN400_RS13075	2611909..2614719	+	2811	WP_014551840.1	GPMC system transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-123)

Antitoxin

• SpoVT-AbrB domain (7-53)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14702.12 Da
• Isoelectric Point: 4.8615

>T26804 WP_010943110.1 NC_017454:c2611098-2610697 [Geobacter sulfurreducens KN400]
MKLLLDTNICIYIIKQQPVAVLERFLEYQVGDIGISSITLSELRYGVAKSTHMEKNAKALDEFIIPLELVSYDESAAHVY
GDIRAALEKAGTPIGSMDMLIAAHAVSLGIPLVTNNTREFLRVPSLNIIDWTV

Nucleotide

• Length: 402 bp

>T26804 NC_017454:c2611098-2610697 [Geobacter sulfurreducens KN400]
ATGAAATTGCTTCTCGACACCAATATCTGCATTTACATCATAAAGCAGCAGCCGGTTGCTGTACTTGAGCGTTTCTTAGA
GTACCAGGTTGGCGATATTGGCATTTCATCCATAACTCTCTCGGAATTGCGCTACGGAGTTGCGAAGAGCACCCATATGG
AGAAAAACGCCAAGGCCCTCGACGAATTCATCATTCCTTTGGAATTGGTTTCTTATGATGAATCGGCGGCTCATGTCTAT
GGAGATATTCGAGCAGCTCTTGAAAAAGCTGGTACGCCCATTGGCTCCATGGATATGTTGATTGCCGCTCACGCTGTATC
GTTAGGAATCCCTCTGGTCACTAATAACACCCGCGAGTTTTTACGGGTCCCTTCCCTCAATATCATTGATTGGACGGTTT
AG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8772.02 Da
• Isoelectric Point: 10.5623

>AT26804 WP_010943111.1 NC_017454:c2611325-2611098 [Geobacter sulfurreducens KN400]
MKTAKIFQNGQSQAVRLPKEFRFEDSEVFIKKSGNVVQLIPRSDSWNSLFGSLKKFSRDFMSERIQPELDKRDGF

Nucleotide

• Length: 228 bp

>AT26804 NC_017454:c2611325-2611098 [Geobacter sulfurreducens KN400]
ATGAAAACTGCAAAGATTTTTCAAAATGGACAAAGTCAGGCAGTAAGGCTTCCCAAAGAATTTCGCTTCGAAGACAGCGA
AGTATTCATCAAGAAAAGCGGCAACGTCGTTCAACTGATCCCTCGGAGCGATTCGTGGAATTCCCTCTTCGGCAGTCTCA
AGAAATTCTCCCGCGATTTCATGTCCGAGCGCATACAACCTGAACTGGACAAGCGGGATGGCTTCTGA

Structures

Toxin

• AlphaFold DB: Q74AB8

Antitoxin

• AlphaFold DB: Q74AB7