Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4196059..4196556 Replicon chromosome
Accession NZ_CP116110
Organism Escherichia coli strain DETEC-P80

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag PIC84_RS20705 Protein ID WP_001173343.1
Coordinates 4196059..4196232 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag PIC84_RS20710 Protein ID WP_000398619.1
Coordinates 4196260..4196556 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC84_RS20695 (4192729) 4192729..4194186 + 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -
PIC84_RS20700 (4194423) 4194423..4195940 + 1518 WP_272756095.1 lysine--tRNA ligase -
PIC84_RS20705 (4196059) 4196059..4196232 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
PIC84_RS20710 (4196260) 4196260..4196556 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
PIC84_RS20715 (4196783) 4196783..4197055 - 273 WP_000405651.1 GNAT family N-acetyltransferase -
PIC84_RS20720 (4197067) 4197067..4197297 - 231 WP_000371704.1 4Fe-4S mono-cluster protein YjdI -
PIC84_RS20725 (4197478) 4197478..4199109 + 1632 WP_001216477.1 sensor histidine kinase -
PIC84_RS20730 (4199106) 4199106..4199825 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T268036 WP_001173343.1 NZ_CP116110:c4196232-4196059 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT268036 WP_000398619.1 NZ_CP116110:c4196556-4196260 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References