Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3402519..3403137 Replicon chromosome
Accession NZ_CP116110
Organism Escherichia coli strain DETEC-P80

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag PIC84_RS16750 Protein ID WP_001291435.1
Coordinates 3402919..3403137 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag PIC84_RS16745 Protein ID WP_000344800.1
Coordinates 3402519..3402893 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC84_RS16735 (3397608) 3397608..3398801 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PIC84_RS16740 (3398824) 3398824..3401973 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
PIC84_RS16745 (3402519) 3402519..3402893 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
PIC84_RS16750 (3402919) 3402919..3403137 + 219 WP_001291435.1 HHA domain-containing protein Toxin
PIC84_RS16755 (3403309) 3403309..3403860 + 552 WP_000102564.1 maltose O-acetyltransferase -
PIC84_RS16760 (3403976) 3403976..3404446 + 471 WP_000136192.1 YlaC family protein -
PIC84_RS16765 (3404610) 3404610..3406160 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
PIC84_RS16770 (3406202) 3406202..3406555 - 354 WP_000878140.1 DUF1428 domain-containing protein -
PIC84_RS16780 (3406934) 3406934..3407245 + 312 WP_000409911.1 MGMT family protein -
PIC84_RS16785 (3407276) 3407276..3407848 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T268032 WP_001291435.1 NZ_CP116110:3402919-3403137 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT268032 WP_000344800.1 NZ_CP116110:3402519-3402893 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References