Detailed information of TA system TA026803

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 2575221..2575746
• Replicon: chromosome
• Accession: NC_017454
• Organism: Geobacter sulfurreducens KN400

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q74AD7
• Locus tag: KN400_RS12905
• Protein ID: WP_010943076.1
• Coordinates: 2575456..2575746 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q74AD8
• Locus tag: KN400_RS12900
• Protein ID: WP_010943075.1
• Coordinates: 2575221..2575466 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KN400_RS12880	2571323..2572030	-	708	WP_014551814.1	lipoyl(octanoyl) transferase LipB	-
KN400_RS12885	2572059..2573315	-	1257	WP_014551815.1	2-oxo acid dehydrogenase subunit E2	-
KN400_RS12890	2573331..2574317	-	987	WP_010943073.1	alpha-ketoacid dehydrogenase subunit beta	-
KN400_RS12895	2574358..2574843	-	486	WP_014551816.1	VOC family protein	-
KN400_RS12900	2575221..2575466	+	246	WP_010943075.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
KN400_RS12905	2575456..2575746	+	291	WP_010943076.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KN400_RS12910	2575795..2576211	-	417	WP_014551817.1	hypothetical protein	-
KN400_RS12915	2576339..2577085	-	747	WP_014551818.1	class I SAM-dependent methyltransferase	-
KN400_RS12920	2577310..2578332	-	1023	WP_014551819.1	RelA/SpoT domain-containing protein	-
KN400_RS12925	2578398..2578871	-	474	WP_010943080.1	hypothetical protein	-
KN400_RS12935	2579090..2580067	-	978	WP_014551820.1	pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-82)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-67)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11331.30 Da
• Isoelectric Point: 10.4995

>T26803 WP_010943076.1 NC_017454:2575456-2575746 [Geobacter sulfurreducens KN400]
MSYSLEFKESALKEWKKLDGRIREQFKKKLTERLELPRVEPARLSGMPDCYKIKLKNAGYRLVYQVDDNRIIVTVVAVGK
RENLTVYRAAEKRVKQ

Nucleotide

• Length: 291 bp

>T26803 NC_017454:2575456-2575746 [Geobacter sulfurreducens KN400]
ATGAGCTATAGCCTCGAATTCAAGGAATCCGCCCTGAAGGAGTGGAAAAAACTCGATGGCAGAATCCGTGAACAGTTTAA
GAAGAAGCTTACCGAACGGCTTGAGCTTCCTCGCGTCGAGCCGGCCCGACTCTCCGGCATGCCCGATTGCTACAAAATCA
AGCTGAAGAACGCCGGCTACCGGCTGGTTTACCAGGTTGACGACAACCGCATCATCGTTACTGTCGTGGCTGTCGGAAAA
CGCGAAAACCTTACCGTTTATCGAGCGGCAGAGAAAAGGGTGAAACAGTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9193.46 Da
• Isoelectric Point: 4.6631

>AT26803 WP_010943075.1 NC_017454:2575221-2575466 [Geobacter sulfurreducens KN400]
MERLFARASVSISDLKKNPTRIINQSEGEPVAILNHNKPSAYLIPADAFEALMEKLEDYELSQIVKEREHEPSVKVSLDE
L

Nucleotide

• Length: 246 bp

>AT26803 NC_017454:2575221-2575466 [Geobacter sulfurreducens KN400]
ATGGAACGTCTTTTTGCCCGTGCCTCGGTCAGCATAAGTGACCTTAAAAAAAACCCCACCCGAATCATTAATCAGTCCGA
AGGTGAACCTGTGGCAATCCTCAACCACAACAAGCCAAGTGCATACTTAATCCCCGCCGATGCCTTCGAGGCGCTCATGG
AGAAACTGGAGGATTATGAGCTTTCCCAAATTGTGAAGGAACGGGAACACGAGCCGAGTGTCAAGGTCTCCCTCGATGAG
CTATAG

Structures

Toxin

• AlphaFold DB: Q74AD7

Antitoxin

• AlphaFold DB: Q74AD8